ID - 131908158 TI - DNA Methyltransferases - Role and Function AU - Jeltsch, Albert AU - Jurkowska, Renata Z. PY - 2022 SN - 9783031114540 9783031114533 9783031114557 9783031114564 PB - Cham Springer International Publishing DB - UniCat KW - Histology. Cytology KW - Enzymology KW - Human genetics KW - medische genetica KW - cytologie KW - histologie KW - enzymen KW - DNA. KW - Methyltransferases. UR - https://www.unicat.be/uniCat?func=search&query=sysid:131908158 AB - This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field. ER -