TY - GEN digital ID - 131780334 TI - Vaccination Strategies Against Highly Variable Pathogens AU - Hangartner, Lars AU - Burton, Dennis R. PY - 2020 SN - 9783030580049 PB - Cham Springer International Publishing DB - UniCat KW - Immunology. Immunopathology KW - Human physiology KW - Medical microbiology, virology, parasitology KW - Infectious diseases. Communicable diseases KW - immunologie KW - virologie KW - besmettelijke ziekten KW - fysiologie KW - vaccinatie UR - https://www.unicat.be/uniCat?func=search&query=sysid:131780334 AB - Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. . ER -