ID - 131771267 TI - Handbook of neuroemergency clinical trials AU - Alves, Wayne M. AU - Skolnick, Brett Evan. PY - 2006 SN - 9780126480825 0126480826 0080454356 9780080454351 1280630787 9781280630781 9780080543109 0080543103 9786610630783 9780120885237 0120885239 0128041013 1281036951 9786611036959 PB - Amsterdam ; Boston : Elsevier Academic Press, DB - UniCat KW - Orthopaedics. Traumatology. Plastic surgery KW - Nervous system KW - Neuropharmacology KW - Clinical trials KW - Diseases KW - Organophosphorus compounds KW - Insecticides KW - Cholinesterase inhibitors KW - Carbamates KW - toxicity KW - poisoning KW - Pesticides KW - Toxicology. UR - https://www.unicat.be/uniCat?func=search&query=sysid:131771267 AB - During the 1990's, scientific advances in understanding the mechanisms and pathophysiology of acute central nervous system injury were offset by a history of disappointing results from Phase III clinical trials of novel neuroprotective drugs. Numerous novel compounds were "tested,? and seemingly fell by the wayside. This book is intended to focus on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. The authors explore the issues facing research in this area and the strategies that might lead to future success in this critical ER -