TY - GEN digital ID - 131712472 TI - Single Cell Sequencing and Systems Immunology PY - 2015 SN - 9789401797535 9789401797542 9789401797528 9789402400649 PB - Dordrecht Springer Netherlands DB - UniCat KW - Genetics KW - Histology. Cytology KW - Biology KW - Immunology. Immunopathology KW - Biotechnology KW - immunologie KW - proteomics KW - biologie KW - cytologie KW - histologie KW - proteïnen UR - https://www.unicat.be/uniCat?func=search&query=sysid:131712472 AB - The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China. . ER -