TY - GEN digital ID - 131708640 TI - Toxicity and Autophagy in Neurodegenerative Disorders PY - 2015 SN - 9783319139395 9783319139401 9783319139388 9783319382128 PB - Cham Springer International Publishing DB - UniCat KW - General biochemistry KW - Physiology of nerves and sense organs KW - neurochemie UR - https://www.unicat.be/uniCat?func=search&query=sysid:131708640 AB - Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays. ER -