TY - GEN digital ID - 131676405 TI - Introduction to Synthetic Biology : About Modeling, Computation, and Circuit Design PY - 2018 SN - 9789811087523 PB - Singapore Springer Singapore, Imprint: Springer DB - UniCat KW - Biology KW - Human biochemistry KW - Biotechnology KW - medische biochemie KW - biologie KW - biomedische wetenschappen KW - biotechnologie UR - https://www.unicat.be/uniCat?func=search&query=sysid:131676405 AB - The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT. ER -