TY - GEN digital ID - 131516991 TI - Hepatitis C Virus: From Molecular Virology to Antiviral Therapy PY - 2013 SN - 9783642273407 PB - Berlin, Heidelberg Springer DB - UniCat KW - Immunology. Immunopathology KW - Pharmacology. Therapy KW - Medical microbiology, virology, parasitology KW - Pathological biochemistry KW - Gastroenterology KW - Human medicine KW - immunologie KW - resistentie (farmacologie) KW - klinische chemie KW - medische biochemie KW - geneesmiddelentolerantie KW - medische virologie KW - farmacologie KW - biochemie KW - biomedische wetenschappen KW - geneeskunde KW - virologie KW - gastro-enterologie KW - leverziekten KW - hepatitis C KW - drugs KW - moleculaire biologie UR - https://www.unicat.be/uniCat?func=search&query=sysid:131516991 AB - Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted. ER -