TY - GEN digital ID - 131511931 TI - DNA Helicases and DNA Motor Proteins PY - 2013 SN - 9781461450375 PB - New York, NY Springer DB - UniCat KW - Histology. Cytology KW - General biochemistry KW - Human biochemistry KW - Human genetics KW - Pathological biochemistry KW - Human medicine KW - medische biochemie KW - medische genetica KW - biochemie KW - biomedische wetenschappen KW - genetica KW - cytologie KW - histologie KW - moleculaire biologie KW - enzymen UR - https://www.unicat.be/uniCat?func=search&query=sysid:131511931 AB - In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system. ER -