TY - GEN digital ID - 131511623 TI - Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication PY - 2013 SN - 9781461436973 PB - New York, NY Springer DB - UniCat KW - Chemical structure KW - Organic spectroscopy KW - Histology. Cytology KW - General biochemistry KW - Molecular biology KW - Immunology. Immunopathology KW - Oncology. Neoplasms KW - Pathological biochemistry KW - Human medicine KW - biosynthese KW - immunologie KW - massaspectrometrie KW - tumoren KW - medische biochemie KW - polypeptiden KW - protein-engineering KW - biochemie KW - biomedische wetenschappen KW - oncologie KW - cytologie KW - genetische manipulatie KW - histologie KW - eiwitten KW - moleculaire biologie KW - proteïnen KW - aminozuren UR - https://www.unicat.be/uniCat?func=search&query=sysid:131511623 AB - Tumor exsome-mediated cell-cell communication has grown increasingly important in cancer research. Recent findings on vesicle-based information transfer by exosomes have changed our view of the tumor microenvironment.  Currently, exosomes represent the main extracellular processes implicated in the regulation of multiple physiological processes. Importantly, in cancer, exosomes contribute to the formation of the tumor microenvironment, promoting invasion, angiogenesis, immune regulation and metastasis. Therefore, exosomes could be considered one of the major forces acting locally or systemically to promote the continuous crosstalk between the tumor and its microenvironment, influencing the behavior of different cell types such as stromal, endothelial and bone marrow-derived cells. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. This volume gives a comprehensive review on current research in this area and also discuss future prospects as prognostic markers for cancer. ER -