TY - JOUR ID - 129001762 TI - Involvement of the prelimbic-infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning. AU - Kesner, R. P. AU - Ragozzino, M. E. AU - Detrick, S. PY - 1999 DB - UniCat KW - Acquisition. KW - Animal-models. KW - Anterior cingulate. KW - Area. KW - Attentional set shifting. KW - Cannula. KW - Caudate-nucleus. KW - City. KW - Cortex. KW - Discrimination. KW - Double dissociation. KW - Electrolytic lesions. KW - Experiment. KW - Experiments. KW - Flexibility. KW - Group. KW - Hippocampal. KW - Infralimbic. KW - Involvement. KW - Learning. KW - Prefrontal cortex. KW - Prelimbic. KW - Rat. KW - Rats. KW - Response. KW - Reversal learning. KW - Rodent. KW - Spatial. KW - Strategies. KW - Strategy. KW - Tasks. KW - Test. KW - Tests. KW - Tetracaine. KW - Working-memory. UR - https://www.unicat.be/uniCat?func=search&query=sysid:129001762 AB - The present experiments investigated the role of the prelimbic-infralimbic areas in behavioral flexibility using a place-response learning paradigm. All rats received a bilateral cannula implant aimed at the prelimbic-infralimbic areas. To examine the role of the prelimbic-infralimbic areas in shifting strategies, rats were tested on a place and a response discrimination in a cross-maze. Some rats were tested on the place version first followed by the response version. The procedure for the other rats was reversed. Infusions of 2% tetracaine into the prelimbic-infralimbic areas did not impair acquisition of the place or response discriminations. Prelimbic-infralimbic inactivation did impair learning when rats were switched from one discrimination to the other (cross-modal shift). To investigate the role of the prelimbic-infralimbic areas in intramodal shifts (reversal learning), one group of rats was tested on a place reversal and another group tested on a response reversal. Prelimbic-infralimbic inactivation did not impair place or response intramodal shifts. Some rats that completed testing on a particular version in the cross-modal and intramodal experiments were tested on the same version in a new room for 3 d. The transfer tests revealed that rats use a spatial strategy on the place version and an egocentric response strategy on the response version. Overall, these results suggest that the prelimbic-infralimbic areas are important for behavioral flexibility involving crossmodal but not intramodal shifts ER -