TY - THES ID - 127566276 TI - Cellular interactions between cancer cells and macrophages AU - Peeters, Jana AU - Hogeschool Gent AU - FMW AU - Vesalius Hogeschool Gent AU - Leroy, Ancy PY - 2012 PB - Gent : [s.n.], DB - UniCat UR - https://www.unicat.be/uniCat?func=search&query=sysid:127566276 AB - The development of cancer is not only dependant on genetic alterations in malign cells but also on their interaction with the microenvironment. Chemokines, cytokines and prostaglandins mediate interactions between cancer cells and their surrounding cells, positively or negatively influencing the development of the tumour. Already in the 19th century researchers observed inflammatory cells present in tumour biopsies but only recently the importance of inflammation became a subject of focus. Clinical and experimental studies evidenced that macrophages are able to influence the invasive capacity of cancer cells and to promote angiogenesis and matrix breakdown. In this study we focused on the migration of cancer cells, which is an important aspect for invasion and metastasis. As no studies have been made yet focusing on in vitro direct interactions of colorectal cancer cells and macrophages, we established co-cultures of these cells and analyzed their migration and shape. By doing this, we hope to bring new insights in the interactions between cancer cells and macrophages and open new perspectives regarding cancer treatment. ER -