TY - BOOK ID - 113601528 TI - Current Insights on Lipid-Based Nanosystems AU - Silva, Ana Catarina AU - Moreira, João AU - Sousa Lobo, José Manuel PY - 2022 SN - 303656165X 3036561668 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Technology: general issues KW - Echinococcus granulosus KW - scolicidal KW - nanoliposome KW - juglone KW - apoptotic activity KW - hydrogel KW - SLNs KW - nose-to-brain delivery KW - mucoadhesion KW - quality by design KW - antioxidant activity KW - nasal administration KW - nanostructured lipid carriers KW - solid lipid nanoparticles KW - in vitro cell cultures KW - 3D nasal casts KW - lung cancer KW - targeted drug delivery KW - lipid-based nanocarriers KW - pulmonary delivery KW - dry powder inhalers KW - aerosols KW - liposomes KW - nanoemulsions KW - nanotechnology KW - biologically active compounds KW - dermal drug delivery KW - polyphenols KW - phytophenols KW - skin permeation KW - chemotherapy KW - radiotherapy KW - active targeting KW - passive targeting KW - tumor KW - immunoconjugate KW - traditional liposome KW - stealth liposome KW - triggered release KW - limitations of liposomes KW - drug transfer KW - in vitro release KW - colloidal drug carriers KW - lipid nanoparticles KW - hydrogel beads KW - cholesteryl nonanoate KW - bovine serum albumin KW - skin diseases KW - lipid-based nanosystems KW - cream KW - ointment KW - gel KW - pH-sensitive KW - liposome KW - imidazole KW - anticancer KW - drug delivery KW - multicellular spheroids KW - dapagliflozin KW - Box–Behnken design KW - FTIR KW - DSC KW - XRD KW - SEM KW - AFM KW - in vitro Franz diffusion cells KW - lipid-based nanoparticles KW - nanocarrier KW - surface charge KW - delivery systems KW - chronic treatment KW - mice KW - anti-oxidant activity KW - hepatoprotective effect KW - phospholipid KW - phytosomes KW - Silymarin KW - Colorectal Cancer KW - Niosomes KW - Oxaliplatin KW - Paclitaxel KW - d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) KW - therapeutic nucleic acids KW - schizophrenia KW - quetiapine fumarate KW - glycerosomes KW - central composite rotatable design KW - bioavailability KW - pharmacokinetic KW - n/a KW - Box-Behnken design UR - https://www.unicat.be/uniCat?func=search&query=sysid:113601528 AB - Lipid-based nanosystems, including solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), cationic lipid nanoparticles, nanoemulsions, and liposomes, have been extensively studied to improve drug delivery through different administration routes. The main advantages of these systems are their ability to protect, transport, and control the release of lipophilic and hydrophilic molecules (either small-molecular-weight molecules or macromolecules); the use of generally recognized as safe (GRAS) excipients that minimize the toxicity of the formulations; and the possibility to modulate pharmacokinetics and enable the site-specific delivery of encapsulated payloads. In addition, the versatility of lipid-based nanosystems has further been demonstrated for the delivery of vaccines, the protection of active cosmetic ingredients, and the improvement of moisturizing properties of cosmetic formulations.Lipid-based nanosystems are well established and there are already different commercially approved formulations for various human disorders. This success has paved the way for the diversification of the pipeline of development, to address unmet medical needs for several indications, such as cancer, neurological disorders, and autoimmune, genetic, and infectious diseases.This Special Issue aims to update readers on the latest research on lipid-based nanosystems, both at the preclinical and clinical levels. A series of 15 articles (six reviews and nine studies) is presented, with authors from 12 different countries, showing the globality of the investigations that are being carried out in this area. ER -