TY - BOOK ID - 113600068 TI - Pathophysiology of Spinal Cord Injury (SCI) AU - Geoffroy, Cédric AU - Alilain, Warren PY - 2022 SN - 303655887X 3036558888 PB - Basel MDPI - Multidisciplinary Digital Publishing Institute DB - UniCat KW - Medicine KW - Neurosciences KW - micturition KW - external urethral sphincter KW - spinal cord injury KW - serotonin KW - electromyogram KW - fecal microbiota transplant KW - inflammation KW - anxiety KW - rehabilitation KW - autonomic dysreflexia KW - immune dysfunction KW - SCI-IDS KW - primary afferents KW - nociceptor KW - reach-to-grasp KW - forelimb function KW - upper extremity function KW - cardiovascular KW - contusion KW - neuroplasticity KW - osteopenia KW - bone loss KW - recovery of function KW - monoamines KW - GABA KW - neuromodulation KW - pain KW - spasticity KW - ionic plasticity KW - repetitive transcranial magnetic stimulation KW - phrenic motor network KW - motoneuron excitability KW - diaphragm muscle KW - spinal cord injury severity KW - cardiometabolic disease KW - liver and cardiac dysfunctions KW - fibrosis KW - pathophysiology KW - oxidative stress KW - contusion model KW - respiratory function KW - diaphragmatic activity KW - phrenic motoneurons KW - neuroinflammation KW - cytokines KW - tumor necrosis factor KW - immune cells KW - microglia UR - https://www.unicat.be/uniCat?func=search&query=sysid:113600068 AB - Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions. ER -