TY - BOOK ID - 11326036 TI - Complex enzymes in microbial natural product biosynthesis. PY - 2009 VL - 458 SN - 00766879 SN - 0123745888 9780123745880 9786612285653 1282285653 0080923356 PB - Amsterdam ; Boston : Academic Press, DB - UniCat KW - Anti-Bacterial agents -- Biosynthesis. KW - Biological products -- Biosynthesis. KW - Carbohydrates -- Biosynthesis. KW - Peptide Biosynthesis KW - Biological Products KW - Anti-Bacterial Agents KW - Polyketide Synthases KW - Enzymes KW - Carbohydrates KW - Complex Mixtures KW - Enzymes and Coenzymes KW - Anti-Infective Agents KW - Biochemical Processes KW - Multienzyme Complexes KW - Metabolism KW - Chemicals and Drugs KW - Carbon-Carbon Ligases KW - Biochemical Phenomena KW - Ligases KW - Therapeutic Uses KW - Metabolic Phenomena KW - Chemical Processes KW - Phenomena and Processes KW - Chemical Phenomena KW - Pharmacologic Actions KW - Chemical Actions and Uses KW - Biosynthesis. KW - Peptides KW - Polyketides KW - Synthesis. KW - Microbial biotechnology. KW - Carbs (Carbohydrates) KW - Peptide synthesis KW - Acetogenins KW - Biological synthesis KW - Synthesis, Biological KW - Microorganisms KW - Biotechnology KW - Biomolecules KW - Organic compounds KW - Glycomics KW - Ketenes KW - Polymers KW - Biochemical engineering KW - Biochemistry KW - Synthetic biology KW - Biochemical templates KW - Industrial microbiology KW - Biotechnological microorganisms KW - Synthesis UR - https://www.unicat.be/uniCat?func=search&query=sysid:11326036 AB - Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been ER -