TY - BOOK ID - 10644640 TI - Autophagy in mammalian systems. PY - 2009 SN - 0123745470 9786612954160 1282954164 0080923259 9780123745477 PB - San Diego, CA ; London : Academic, DB - UniCat KW - Apoptosis. KW - Autophagic vacuoles. KW - Autophagy. KW - Cellular control mechanisms. KW - Eukaryotic cells. KW - Cell Death KW - Nerve Tissue Proteins KW - Phagocytosis KW - Anatomy KW - Investigative Techniques KW - Vertebrates KW - Microtubule Proteins KW - Cytoskeletal Proteins KW - Cell Physiological Processes KW - Proteins KW - Analytical, Diagnostic and Therapeutic Techniques and Equipment KW - Chordata KW - Endocytosis KW - Biological Assay KW - Autophagy KW - Microtubule-Associated Proteins KW - Cells KW - Mammals KW - Animals KW - Cell Physiological Phenomena KW - Amino Acids, Peptides, and Proteins KW - Eukaryota KW - Phenomena and Processes KW - Chemicals and Drugs KW - Organisms KW - Human Anatomy & Physiology KW - Biology KW - Health & Biological Sciences KW - Cytology KW - Animal Biochemistry KW - Eucaryotic cells KW - Autophagocytosis KW - Cell regulation KW - Protista KW - Cell death KW - Biological control systems KW - Cell metabolism UR - https://www.unicat.be/uniCat?func=search&query=sysid:10644640 AB - Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal "house-cleaning? in the cell is called autophagy - literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 in yeast. These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn o ER -