TY - BOOK ID - 101207756 TI - Antisense RNA Design, Delivery, and Analysis AU - Arechavala-Gomeza, Virginia AU - Arechavala-Gomeza, Virginia. AU - Garanto, Alejandro. PY - 2022 SN - 107162010X 1071620096 PB - New York Springer Nature DB - UniCat KW - Therapeutics. KW - Biomaterials. KW - Nucleic acids. KW - Nucleic Acid. KW - Polynucleotides KW - Biomolecules KW - Medical treatment KW - Therapy KW - Treatment of diseases KW - Treatments for diseases KW - Clinical medicine KW - RNA therapeutics KW - Antisense technology KW - Therapeutic design KW - Oligonucleotides KW - Model systems KW - Oligonucleotide-mediated toxicology KW - Open Access KW - Àcids nuclèics KW - RNA KW - Teràpia genètica KW - Teràpia gènica KW - Terapèutica genètica KW - Enginyeria genètica KW - Terapèutica KW - Àcid ribonucleic KW - ARN KW - Àcids nucleics KW - Micro RNAs KW - Biomolècules KW - ADN KW - Nucleoproteïnes KW - Transformació genètica KW - Àcids nucleics. UR - https://www.unicat.be/uniCat?func=search&query=sysid:101207756 AB - This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries. ER -