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The 'WHO Bacterial Priority Pathogens List, 2024' is a comprehensive guide developed by the World Health Organization to identify bacterial pathogens of significant public health importance. The report aims to direct research, development, and strategies to combat antimicrobial resistance. It highlights the critical need to address gram-negative bacterial pathogens and drug-resistant tuberculosis (RR-TB) as high priorities. The document is intended for scientists, policymakers, and healthcare professionals involved in public health and antimicrobial resistance. It includes detailed evaluations of bacterial pathogens using Multiple Criteria Decision Analysis (MCDA), providing a framework for prioritizing research and innovation in drug development and public health interventions.

Drug resistance in microorganisms. --- Multidrug-resistant tuberculosis.

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This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing Combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.

Drug Resistance, Neoplasm. --- Immunotherapy. --- Tumor Microenvironment. --- Neoplasms --- drug therapy. --- Cancer. --- Cancer --- Cancer Biology. --- Cancer Microenvironment. --- Cancer Therapy. --- Treatment. --- Drug resistance --- Drug resistance in cancer cells. --- Chemotherapy. --- Neoplasm. --- Antineoplastic Agents --- Tumor Microenvironment --- Neoplastic Stem Cells --- drug effects.

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This book addresses the pressing problem of drug resistance in the treatment of breast cancer. It provides a comprehensive understanding of the complex mechanisms underlying drug resistance and presents the latest advances in therapeutic approaches to overcome this enormous challenge. The book begins with an introduction to the biology of breast cancer, treatment modalities and the mechanisms of drug resistance. This includes the principles of drug resistance in targeted, immune-, endocrine and chemotherapy. In the following sections, the authors present innovative strategies to overcome drug resistance and new research directions, among others the role of the microbiome in drug resistance, molecular profiling of patients for personalized medical care, and new drug delivery systems. Finally, the book concludes with a discussion of the differences in the prevalence and treatment success of breast cancer between high- and low-income countries. This book is an informative resource for students, researchers, and clinicians in the field of breast cancer research and oncology in general.

Breast Neoplasms. --- Drug Resistance. --- Cancer --- Cancer. --- Nanomedicine. --- Oncology. --- Cancer Therapy. --- Cancer Nanotechnology. --- Treatment.

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This book discusses the key problems and solutions with various applicable approaches to combat antibiotic-resistant genes in industrial waste water. Several genes are selected within the chapters to illustrate the past and future roles of molecular ecophysiology and genomics in the development of wastewater microbiology as an important subdiscipline of microbial ecology. As we have very limited knowledge of composition, dynamics and stability of microbial communities, various processes in wastewater treatment have been generally considered to be "black box." In recent years, with the development of several new high throughput sequencing platforms, metagenome sequencing strategies and bioinformatics toolboxes, the analysis of the genome of complex communities has become much more accessible and means easier. The opening of the biological wastewater treatment “black box” is not the unpleasant experience it was before. The viable, but not cultural, ceases to be the inconsequential, uncharacterizable enigma that existed today. Metagenomics leads the way for more specific studies in related fields. Finally, genomic studies of wastewater treatment microbes, in addition to their biotechnological applications, are also an excellent testing ground for variety of other ecological and environmental burns questions. Wastewater treatment plants are considered hotspots for the environmental dissemination of antimicrobial-resistant determinants. Comparative genomics of antibiotic resistant genes isolated from conventional activated sludge and biological aerated filter wastewater treatment plants is discussed.

Refuse and refuse disposal. --- Environment. --- Water. --- Hydrology. --- Environmental engineering. --- Biotechnology. --- Bioremediation. --- Environmental chemistry. --- Waste Management/Waste Technology. --- Environmental Sciences. --- Environmental Engineering/Biotechnology. --- Environmental Chemistry. --- Drug resistance in microorganisms --- Sewage --- Genetic aspects. --- Microbiology. --- Purification.