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This dissertation by Anna Wehlin explores the structural and functional mechanisms of PLAAT-family proteins and their evolutionary repurposing in picornaviruses. The research focuses on the human protein PLAAT3, a host factor facilitating viral genome transfer, and its homolog, PLAAT4. The study investigates how these proteins, especially PLAAT3, are involved in the viral lifecycle, potentially offering insights into antiviral drug targets. The thesis also examines viral 2A proteins that mimic PLAAT3's function through horizontal gene transfer, aiming to understand their role in bypassing human host factors. The work is aimed at scientists and researchers in biochemistry and virology, seeking to advance knowledge of virus-host interactions and therapeutic developments.
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Parasitic diseases --- Civilization --- Parasites --- History. --- Social aspects. --- Host-Parasite Interactions --- Parasitic Diseases --- History of Medicine --- Parasite --- Parasite Load --- Medicine, History --- History Medicines --- Medicine Histories --- Medicines, History --- Medicine --- Host-Parasite Relationship --- Parasite-Host Interactions --- Host-Parasite Relations --- Parasite-Host Relations --- Host Parasite Interactions --- Host Parasite Relations --- Host Parasite Relationship --- Host-Parasite Interaction --- Host-Parasite Relation --- Host-Parasite Relationships --- Interaction, Host-Parasite --- Interaction, Parasite-Host --- Interactions, Host-Parasite --- Interactions, Parasite-Host --- Parasite Host Interactions --- Parasite Host Relations --- Parasite-Host Interaction --- Parasite-Host Relation --- Relation, Host-Parasite --- Relation, Parasite-Host --- Relations, Host-Parasite --- Relations, Parasite-Host --- Relationship, Host-Parasite --- Relationships, Host-Parasite --- history
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Host-bacteria relationships --- Bacterial diseases --- Host-bacteria relationships. --- Bacterial diseases. --- Bacterial infections --- Communicable diseases --- Medical bacteriology --- Pathogenic bacteria --- Bacteria-host relationships --- Relationships, Host-bacteria --- Host-parasite relationships --- Host Microbial Interactions --- Bacteria --- Bacterial Physiological Phenomena --- Bacterial Infections --- Adaptation, Biological
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Microbiome Therapeutics: Personalized Therapy Beyond Conventional Approaches addresses the current knowledge and landscape of microbiome therapeutics, providing an overview of existing applications in health and disease as well as potential future directions of microbiome modulations and subsequent translation to the global industry and market. This important reference provides the most current status of microbiome therapeutics as well as possible future perspectives through coverage of topics including the application of microbiome therapeutics; various additive, subtractive and modulatory approaches; microbiome composition of health and diseases, insights into live bio-therapeutics and the clinical data supporting their efficacy. Case studies are provided throughout the book to further define, describe and evaluate microbiome therapeutics success and failure.
Microorganisms --- Type specimens. --- Type specimens (Natural history) --- Host Microbial Interactions --- Gastrointestinal Microbiome --- Biological Therapy --- methods
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This book covers all aspects of naturally occurring phenomenon of Plant-Pathogen Interaction (PPI). Recent findings and scientific explanations to understand PPI are provided accompanied by numerous helpful photographs and pictorial presentations. In addition, tabulated data is also included to aid in getting insight into the subject and identifying the missing links. Essential information is provided on physiological, biochemical and pathology consequences of PPI and distinguished sections are devoted to explain molecular and regulatory mechanism underlying PPI. Further topics include different classes of plant pathogen, receptor molecules, signaling system, secondary metabolism and plant defense system etc. This book helps the readers in understanding the state of art and emerging technics to explore PPI and in identifying the missing links which further help in creating the background for future exploration of PPI in terms of experimental and technical advancements. .
Plant diseases. --- Stress (Physiology). --- Plants. --- Plant physiology. --- Plant Pathology. --- Plant Stress Responses. --- Plant Physiology. --- Host-parasite relationships.
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Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine sheds new light on various applications of microbial metabolites in the biomedical sector. The purpose of this book is to integrate the latest research advancements on the application of microbial metabolites in the medical industry into a single platform. In 10 chapters, the significance of biomedical applications and future therapeutic applications of microbial metabolites in human health are highlighted. Several chapters are dedicated to the role of microbial metabolites in precision medicine like the impact of the activities of microbial metabolites in antitumor and antidiabetic agents and immunosuppressive activities. It also provides a roadmap for drugs discovery based on antimicrobial products and the effect of microbial metabolites on humans’ health and the immune system. The book finalizes with a chapter on the use of microbial metabolites in OMICS technology. Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine targets researchers from both academia and industry, professors, and graduate students from microbiology, molecular biology, biotechnology, and immunology.
Metabolism. --- Microbial biotechnology. --- Microbial metabolites. --- Metabolites --- Microorganisms --- Biotechnology --- Industrial microbiology --- Biotechnological microorganisms --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Host Microbial Interactions --- Microbiota --- Dysbiosis --- Metabolomics
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Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases. Offers an alternative, natural approach to the prevention of vector-borne diseases Discusses the current and future perspectives of vector-borne diseases and natural product management ; Covers the properties of plants extracts and their phytoactives in vector-borne disease management ; Explores the advantages and disadvantages of natural products versus western medicine for treatment of vector-borne diseases.
Natural products. --- Vector-pathogen relationships. --- Disease management. --- Clinical medicine --- Health services administration --- Medical care --- Pathogen-vector relationships --- Animals as carriers of disease --- Host-parasite relationships --- Products, Natural --- Raw materials --- Decision making --- Cost control --- Disease Management --- Biological Products --- Vector Borne Diseases --- therapeutic use
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This book is a continuation of the topic of “DAMPs in Human Diseases”, the basics of which were described in a first volume, and details of their role in polytrauma, solid organ injuries, atherosclerosis, and cerebrocardiovascular diseases in a second volume by the same author. The third volume presents our current understanding of the impact of DAMP-driven innate/adaptive immune responses on the etiopathogenesis of antigen-related disorders, focusing on infectious and autoimmune diseases (highlighting respiratory virus diseases such as COVID-19, bacterial sepsis, and malaria) and autoimmune diseases (emphasizing systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes), and briefly discussing allograft and tumor rejection. The detailed description and illustration of DAMP-triggered inflammatory pathways in the various chapters explain, for example, why it is the dysregulated emission of DAMPs - and not the virus or the bacterium per se- that is responsible for admitting COVID-19 or sepsis patients to the ICU for intensive care treatment. Also, the chapters on autoimmune diseases explain why, mechanistically, environmental factors make up a significant part of the risk in disease initiation and propagation. Our growing understanding of such deleterious pathogenetic functions of activating DAMPs and suppressing DAMPs (SAMPs) is used as a point of departure to explore how these molecules can be used as valuable diagnostic and prognostic biomarkers as well as future therapeutic targets and therapeutics. The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists.
Internal medicine. --- Immunology. --- Allergy. --- Natural immunity. --- Internal Medicine. --- Allergology. --- Innate Immunity. --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Immunobiology --- Life sciences --- Serology --- Medicine, Internal --- Medicine --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Antigen-antibody reactions. --- Diseases --- Molecular aspects. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Pathology --- Sick --- Antibody-antigen reactions --- Antigens --- Immune response --- Immunoglobulins --- Immunology
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Refugees and displaced people rarely figure as historical actors, and almost never as historical narrators. We often assume a person residing in a refugee camp, lacking funding, training, social networks, and other material resources that enable the research and writing of academic history, cannot be a historian because a historian cannot be a person residing in a refugee camp. The Right to Research disrupts this tautology by featuring nine works by refugee and host-community researchers from across Africa, Europe, and the Middle East. Identifying the intrinsic challenges of making space for diverse voices within a research framework and infrastructure that is inherently unequal, this edited volume offers a critical reflection on what history means, who narrates it, and what happens when those long excluded from authorship bring their knowledge and perspectives to bear. Chapters address topics such as education in Kakuma Refugee Camp, the political power of hip-hop in Rwanda, women migrants to Yemen, and the development of photojournalism in Kurdistan. Exploring what it means to become a researcher, The Right to Research understands historical scholarship as an ongoing conversation - one in which we all have a right to participate.
History --- Narrative inquiry (Research method) --- Refugees --- Research. --- Africa. --- Burundi. --- Eastern Africa. --- Global South. --- Iraq. --- Kenya. --- Kurdistan. --- Middle East. --- Rwanda. --- Syria. --- Twa. --- UNHCR. --- United Nations. --- Yemen. --- archives. --- asylum. --- border-crossing. --- borders. --- colonization. --- conversation. --- dance. --- dialogue. --- displacement. --- education. --- epistemology. --- forced migration. --- gender. --- global history. --- healthcare. --- hip-hop. --- history. --- host community. --- humanitarianism. --- inclusion. --- labour. --- method. --- migration. --- non-profits. --- pedagogy. --- photojournalism. --- pottery. --- refugee camps. --- refugee studies. --- refugee. --- rights. --- silence. --- strangers. --- translocal. --- voice. --- youth. --- Research
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