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Polycystic ovary syndrome. --- PCOD (Gynecology) --- PCOS (Gynecology) --- Polycystic ovarian disease --- Polyfollicular ovarian disease --- Sclerocystic ovarian degeneration --- Sclerocystic ovaries --- Sclerocystic ovary syndrome --- Stein-Leventhal syndrome --- Ovaries --- Syndromes --- Hyperandrogenism --- Cysts

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Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.

n/a --- lipids --- cathepsins --- neurodegeneration --- tocilizumab --- SGBS adipocytes --- chemerin receptors --- cholesterol --- metabolically healthy obese --- energy metabolism --- adipose-brain axis --- EP3 receptor --- leptin --- rheumatoid arthritis --- excessive gestational weight gain --- in vitro fat regain --- secreted frizzled-related protein 5 --- PCOS --- EP4 receptor --- leukocyte --- exchange protein directly activated by cAMP isoform 2 (EPAC2) --- extracellular remodeling --- insulin --- osteoarthritis --- lipid metabolism --- fat mass --- Tango bioassay --- fatty liver --- free fatty acids --- label-free proteomic profiling --- interleukin(IL)-33 --- sick fat --- polycystic ovary syndrome --- early-life programming --- inflammation --- gestational diabetes --- glucose restriction --- adipokines --- neonatal anthropometry --- epicardial adipose tissue (EAT) --- oestrous cycle --- Cardiovascular Diseases (CVDs) --- triglycerides --- G protein-coupled receptor 1 --- testicular pathologies --- prognosis --- ovary --- ICU --- biologic activity --- preeclempsia --- adipokine --- critical illness --- early pregnancy --- myokine --- liver steatosis --- C-C chemokine receptor-like 2 --- testis --- stimulating growth factor 2 (ST2) --- pig --- fitness --- human granulosa cells --- obesity --- proteolysis --- annexins --- adipose tissue --- biomarker --- ghrelin --- brain health --- sepsis --- adiponectin --- rheumatic diseases --- chemokine-like receptor 1 --- follicular fluid --- glucose homeostasis --- resistin --- Nonalcoholic fatty liver disease --- prostaglandin E2 (PGE2) --- visceral fat --- microglia --- weight regain --- complement factors --- alpha-fetoprotein --- polycystic ovary morphology --- chemerin --- cancer --- depression --- hypertension --- hypothalamus

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Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.

Technology: general issues --- NQO1 --- NQO1*2 --- polymorphism --- quinone --- breast cancer --- menadione --- lapachone --- doxorubicin --- ascorbate --- oxidative stress --- reactive oxygen species --- sperm --- cancer chemotherapy --- antioxidant therapy --- antioxidant proteins --- chemoresistance --- oxaliplatin --- 5-Fluorouracil --- myelodysplastic syndromes --- carbonylation --- deferasirox --- ovary --- calcium channel --- Trolox --- granulosa cell tumor --- cell death --- mitochondria --- photodynamic therapy --- singlet oxygen --- nitric oxide --- light --- combination therapy --- antioxidants --- bleomycin --- cancer treatment --- chemotherapy-induced toxicity --- cisplatin --- free radicals --- methotrexate --- ozone therapy --- lung cancer --- cancer metabolism --- reactive oxygen species (ROS) --- therapy resistance --- new therapeutic strategies --- breast cancer stem cells --- 4-hydroxy-2-nonenal --- extracellular matrix --- NRF2 --- bardoxolone methyl --- prostate cancer --- castration-resistant prostate cancer --- androgen receptor (AR), AR-V7 --- anti-androgen --- enzalutamide --- androgen deprivation therapy --- cancer --- antioxidant --- triphala --- ayurveda --- chemoprevention and chemotherapy --- n/a

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Next year (2018), we will be celebrating the 15th anniversary of the International Journal of Environmental Research and Public Health—IJERPH (ISSN 1660-4601). Hence, we are currently organizing a Special Issue to commemorate this important milestone. Founded in 2004, IJERPH has experienced a tremendous growth in terms of the number and quality of scientific publications. With a 2016 impact factor of 2.101, IJERPH now ranks among the top international journals in the emerging field of environmental research and public health. As described on our website (https://www.mdpi.com/journal/ijerph), IJERPH is a peer-reviewed journal that focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health. Its primary areas of research interests include: Gene-environment interactions Environmental genomics and proteomics Environmental toxicology, mutagenesis and carcinogenesis Environmental epidemiology and disease control Health risk assessment and management Ecotoxicology, and ecological risk assessment and management Natural resources damage assessment Environmental chemistry and computational modeling Environmental policy and management Environmental engineering and biotechnology Emerging issues in environmental health and diseases Environmental education and public health To help celebrate the 15th anniversary, you are kindly invited to submit original articles, critical reviews, research notes, and short communications on any of the above-listed topics. Please also encourage any of our colleagues who may be interested to submit manuscripts. We expect that this issue will attract considerable attention, as we prepare to celebrate the excellent scientific contributions and socio-economic impacts of IJERPH over the past 15 years.

Research & information: general --- transportation noise --- MTNR1B gene --- rs10830963 --- diabetes --- glycosylated hemoglobin --- circadian sleep-wake cycle --- gene-environment interactions --- adults --- cohort study --- metal mobility --- soil flushing --- soil reclamation --- agricultural soil --- EDDS deficiency --- child sexual abuse --- adolescents --- girls --- boys --- gender differences --- legal proceedings --- child-friendly justice --- prevention --- cervical Arabin pessary --- cerclage --- second trimester of pregnancy --- sepiolite --- adsorption --- potentially toxic elements --- modification --- regeneration --- Xiangjiang River --- air pollution --- neighborhood deprivation index --- preterm birth --- spatial approach --- participatory research --- second hand smoking --- communication media --- vulnerable populations --- migrants --- health care research --- quality assurance --- hospital management --- health inequities --- environmental vulnerability --- multi-criteria spatial analysis --- risk management tool --- hazardous substance --- road accidents --- online hate --- hate speech --- bystander --- perpetrator --- online disinhibition --- online discrimination --- cyber aggression --- Bothrops lanceolatus --- envenomation --- snakebite --- bacteria --- infection --- antibiotic susceptibility --- ADL --- disability --- health --- home --- usability --- parenting desire --- lesbian --- gay --- minority stress --- mediation --- demographic factor --- EQ-5D --- health-related quality of life --- depression --- family planning --- Bayesian --- spatial --- RDHS --- Rwanda --- suicide --- premature mortality --- young men --- Greenland --- Denmark --- head injury --- incidence --- national health insurance --- population-based study --- mortality --- traumatic brain injury --- polycystic ovary syndrome --- self-efficacy --- optimism --- acceptance of illness --- September 11 terrorist attacks --- pilot aircraft-assisted suicide --- copycat effect --- obesity --- endoscopy --- Helicobacter pylori --- BMI --- Saudi patients --- urban lake --- comprehensive nutrition status Index --- heavy metals --- health risk --- fuzzy comprehensive method --- physical fitness --- Mediterranean diet --- body composition --- dementia --- health services --- resource utilization --- dementia care --- informal care --- formal care --- cognitive disorder --- physical activity in pregnancy --- PPAQ --- quality of life --- WHOQoL-Bref --- pregnant women --- food availability --- eating away from home --- household food spending --- trace elements --- concentration --- microwave digester --- Wuhan --- soil contamination --- ecological risk --- tuberculosis --- screening for tuberculosis --- public health --- immigrants --- health impact assessments --- premature death --- equity impact --- health impact --- reduction of air pollution --- environmental inequalities --- spatial analysis --- small area --- AirQ --- traffic congestion --- activity-travel patterns --- real-time traffic data --- the uncertain geographic context problem (UGCoP) --- the neighborhood effect averaging problem (NEAP) --- evaluation --- method --- policy --- strategy --- social --- trend --- winter tourism --- climate change --- snow abundance index --- meteorological suitability index --- copula function --- spatial suitability assessment --- oral surgery --- oral medicine --- leucoplakia --- hyperkeratosis --- laser --- electronic waste --- informal recycling --- PBDEs --- soil --- dust --- Nigeria --- aerobic capacity --- attrition --- change-of-direction speed --- deputy sheriff --- graduation --- high-intensity running --- police --- strength endurance --- tactical --- roadside exposure --- inflammation biomarker --- Nepal --- PM2.5 --- oily sludge --- incineration --- kinetic --- modeling --- differential/integral method --- engineering --- curriculum proposals --- arbuscular mycorrhizal fungi --- global change --- grassland ecosystem --- stoichiometry --- phosphorus limitation --- unsafe behavior --- targeted intervention --- coal miners --- safety management --- bioaerosols --- influenza virus --- ferret animal model --- aerosol chamber --- dengue fever --- Aedes albopictus --- living environment --- logistic regression analysis --- China --- human capital --- multilevel linear regression --- self-rated mental health --- social capital --- groundwater --- iron and manganese removal --- biofilter --- food contamination --- gastrointestinal diseases --- morbidity --- deep neural networks --- evolutionary learning --- health literacy --- adolescent health --- Mexico --- health disparities --- motivation --- videogaming --- psychopathology --- adverse childhood experiences (ACEs) --- Hungarian representative adult sample --- opinion poll --- ACE Score Calculator --- influenza vaccination --- pneumonia --- population-based case-control study --- adolescent --- risk factors --- psychosocial --- socio-environmental --- behavior --- United States --- Latinos --- physical education --- social and emotional learning --- sport education model --- subjective well-being --- trait emotional intelligence --- social anxiety --- transportation noise --- MTNR1B gene --- rs10830963 --- diabetes --- glycosylated hemoglobin --- circadian sleep-wake cycle --- gene-environment interactions --- adults --- cohort study --- metal mobility --- soil flushing --- soil reclamation --- agricultural soil --- EDDS deficiency --- child sexual abuse --- adolescents --- girls --- boys --- gender differences --- legal proceedings --- child-friendly justice --- prevention --- cervical Arabin pessary --- cerclage --- second trimester of pregnancy --- sepiolite --- adsorption --- potentially toxic elements --- modification --- regeneration --- Xiangjiang River --- air pollution --- neighborhood deprivation index --- preterm birth --- spatial approach --- participatory research --- second hand smoking --- communication media --- vulnerable populations --- migrants --- health care research --- quality assurance --- hospital management --- health inequities --- environmental vulnerability --- multi-criteria spatial analysis --- risk management tool --- hazardous substance --- road accidents --- online hate --- hate speech --- bystander --- perpetrator --- online disinhibition --- online discrimination --- cyber aggression --- Bothrops lanceolatus --- envenomation --- snakebite --- bacteria --- infection --- antibiotic susceptibility --- ADL --- disability --- health --- home --- usability --- parenting desire --- lesbian --- gay --- minority stress --- mediation --- demographic factor --- EQ-5D --- health-related quality of life --- depression --- family planning --- Bayesian --- spatial --- RDHS --- Rwanda --- suicide --- premature mortality --- young men --- Greenland --- Denmark --- head injury --- incidence --- national health insurance --- population-based study --- mortality --- traumatic brain injury --- polycystic ovary syndrome --- self-efficacy --- optimism --- acceptance of illness --- September 11 terrorist attacks --- pilot aircraft-assisted suicide --- copycat effect --- obesity --- endoscopy --- Helicobacter pylori --- BMI --- Saudi patients --- urban lake --- comprehensive nutrition status Index --- heavy metals --- health risk --- fuzzy comprehensive method --- physical fitness --- Mediterranean diet --- body composition --- dementia --- health services --- resource utilization --- dementia care --- informal care --- formal care --- cognitive disorder --- physical activity in pregnancy --- PPAQ --- quality of life --- WHOQoL-Bref --- pregnant women --- food availability --- eating away from home --- household food spending --- trace elements --- concentration --- microwave digester --- Wuhan --- soil contamination --- ecological risk --- tuberculosis --- screening for tuberculosis --- public health --- immigrants --- health impact assessments --- premature death --- equity impact --- health impact --- reduction of air pollution --- environmental inequalities --- spatial analysis --- small area --- AirQ --- traffic congestion --- activity-travel patterns --- real-time traffic data --- the uncertain geographic context problem (UGCoP) --- the neighborhood effect averaging problem (NEAP) --- evaluation --- method --- policy --- strategy --- social --- trend --- winter tourism --- climate change --- snow abundance index --- meteorological suitability index --- copula function --- spatial suitability assessment --- oral surgery --- oral medicine --- leucoplakia --- hyperkeratosis --- laser --- electronic waste --- informal recycling --- PBDEs --- soil --- dust --- Nigeria --- aerobic capacity --- attrition --- change-of-direction speed --- deputy sheriff --- graduation --- high-intensity running --- police --- strength endurance --- tactical --- roadside exposure --- inflammation biomarker --- Nepal --- PM2.5 --- oily sludge --- incineration --- kinetic --- modeling --- differential/integral method --- engineering --- curriculum proposals --- arbuscular mycorrhizal fungi --- global change --- grassland ecosystem --- stoichiometry --- phosphorus limitation --- unsafe behavior --- targeted intervention --- coal miners --- safety management --- bioaerosols --- influenza virus --- ferret animal model --- aerosol chamber --- dengue fever --- Aedes albopictus --- living environment --- logistic regression analysis --- China --- human capital --- multilevel linear regression --- self-rated mental health --- social capital --- groundwater --- iron and manganese removal --- biofilter --- food contamination --- gastrointestinal diseases --- morbidity --- deep neural networks --- evolutionary learning --- health literacy --- adolescent health --- Mexico --- health disparities --- motivation --- videogaming --- psychopathology --- adverse childhood experiences (ACEs) --- Hungarian representative adult sample --- opinion poll --- ACE Score Calculator --- influenza vaccination --- pneumonia --- population-based case-control study --- adolescent --- risk factors --- psychosocial --- socio-environmental --- behavior --- United States --- Latinos --- physical education --- social and emotional learning --- sport education model --- subjective well-being --- trait emotional intelligence --- social anxiety

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Next year (2018), we will be celebrating the 15th anniversary of the International Journal of Environmental Research and Public Health—IJERPH (ISSN 1660-4601). Hence, we are currently organizing a Special Issue to commemorate this important milestone. Founded in 2004, IJERPH has experienced a tremendous growth in terms of the number and quality of scientific publications. With a 2016 impact factor of 2.101, IJERPH now ranks among the top international journals in the emerging field of environmental research and public health. As described on our website (https://www.mdpi.com/journal/ijerph), IJERPH is a peer-reviewed journal that focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health. Its primary areas of research interests include: Gene-environment interactions Environmental genomics and proteomics Environmental toxicology, mutagenesis and carcinogenesis Environmental epidemiology and disease control Health risk assessment and management Ecotoxicology, and ecological risk assessment and management Natural resources damage assessment Environmental chemistry and computational modeling Environmental policy and management Environmental engineering and biotechnology Emerging issues in environmental health and diseases Environmental education and public health To help celebrate the 15th anniversary, you are kindly invited to submit original articles, critical reviews, research notes, and short communications on any of the above-listed topics. Please also encourage any of our colleagues who may be interested to submit manuscripts. We expect that this issue will attract considerable attention, as we prepare to celebrate the excellent scientific contributions and socio-economic impacts of IJERPH over the past 15 years.

transportation noise --- MTNR1B gene --- rs10830963 --- diabetes --- glycosylated hemoglobin --- circadian sleep-wake cycle --- gene-environment interactions --- adults --- cohort study --- metal mobility --- soil flushing --- soil reclamation --- agricultural soil --- EDDS deficiency --- child sexual abuse --- adolescents --- girls --- boys --- gender differences --- legal proceedings --- child-friendly justice --- prevention --- cervical Arabin pessary --- cerclage --- second trimester of pregnancy --- sepiolite --- adsorption --- potentially toxic elements --- modification --- regeneration --- Xiangjiang River --- air pollution --- neighborhood deprivation index --- preterm birth --- spatial approach --- participatory research --- second hand smoking --- communication media --- vulnerable populations --- migrants --- health care research --- quality assurance --- hospital management --- health inequities --- environmental vulnerability --- multi-criteria spatial analysis --- risk management tool --- hazardous substance --- road accidents --- online hate --- hate speech --- bystander --- perpetrator --- online disinhibition --- online discrimination --- cyber aggression --- Bothrops lanceolatus --- envenomation --- snakebite --- bacteria --- infection --- antibiotic susceptibility --- ADL --- disability --- health --- home --- usability --- parenting desire --- lesbian --- gay --- minority stress --- mediation --- demographic factor --- EQ-5D --- health-related quality of life --- depression --- family planning --- Bayesian --- spatial --- RDHS --- Rwanda --- suicide --- premature mortality --- young men --- Greenland --- Denmark --- head injury --- incidence --- national health insurance --- population-based study --- mortality --- traumatic brain injury --- polycystic ovary syndrome --- self-efficacy --- optimism --- acceptance of illness --- September 11 terrorist attacks --- pilot aircraft-assisted suicide --- copycat effect --- obesity --- endoscopy --- Helicobacter pylori --- BMI --- Saudi patients --- urban lake --- comprehensive nutrition status Index --- heavy metals --- health risk --- fuzzy comprehensive method --- physical fitness --- Mediterranean diet --- body composition --- dementia --- health services --- resource utilization --- dementia care --- informal care --- formal care --- cognitive disorder --- physical activity in pregnancy --- PPAQ --- quality of life --- WHOQoL-Bref --- pregnant women --- food availability --- eating away from home --- household food spending --- trace elements --- concentration --- microwave digester --- Wuhan --- soil contamination --- ecological risk --- tuberculosis --- screening for tuberculosis --- public health --- immigrants --- health impact assessments --- premature death --- equity impact --- health impact --- reduction of air pollution --- environmental inequalities --- spatial analysis --- small area --- AirQ --- traffic congestion --- activity-travel patterns --- real-time traffic data --- the uncertain geographic context problem (UGCoP) --- the neighborhood effect averaging problem (NEAP) --- evaluation --- method --- policy --- strategy --- social --- trend --- winter tourism --- climate change --- snow abundance index --- meteorological suitability index --- copula function --- spatial suitability assessment --- oral surgery --- oral medicine --- leucoplakia --- hyperkeratosis --- laser --- electronic waste --- informal recycling --- PBDEs --- soil --- dust --- Nigeria --- aerobic capacity --- attrition --- change-of-direction speed --- deputy sheriff --- graduation --- high-intensity running --- police --- strength endurance --- tactical --- roadside exposure --- inflammation biomarker --- Nepal --- PM2.5 --- oily sludge --- incineration --- kinetic --- modeling --- differential/integral method --- engineering --- curriculum proposals --- arbuscular mycorrhizal fungi --- global change --- grassland ecosystem --- stoichiometry --- phosphorus limitation --- unsafe behavior --- targeted intervention --- coal miners --- safety management --- bioaerosols --- influenza virus --- ferret animal model --- aerosol chamber --- dengue fever --- Aedes albopictus --- living environment --- logistic regression analysis --- China --- human capital --- multilevel linear regression --- self-rated mental health --- social capital --- groundwater --- iron and manganese removal --- biofilter --- food contamination --- gastrointestinal diseases --- morbidity --- deep neural networks --- evolutionary learning --- health literacy --- adolescent health --- Mexico --- health disparities --- motivation --- videogaming --- psychopathology --- adverse childhood experiences (ACEs) --- Hungarian representative adult sample --- opinion poll --- ACE Score Calculator --- influenza vaccination --- pneumonia --- population-based case-control study --- adolescent --- risk factors --- psychosocial --- socio-environmental --- behavior --- United States --- Latinos --- physical education --- social and emotional learning --- sport education model --- subjective well-being --- trait emotional intelligence --- social anxiety