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"This fully revised Fourth Edition to a best-selling resource provides the reader with a hands-on guide to computational biology, primarily in the area of sequence analysis. The subject matter will cover a broad spectrum of concepts in bioinformatics, beginning with an overview of biological databases and ending with a series of chapters on predictive and comparative algorithms. Using relevant biological examples, the book will provide background on and strategies for using many of the most powerful and commonly-used algorithms for sequence-based discovery. Given the explosion in the number of organisms whose genomes have been sequenced over the last several years, the emergence of new types of data sets (particularly those derived using next-generation sequencing technologies), and increasing emphasis on being able to make effective use of "big data", the book is both timely and important to investigators in molecular biology and related fields. With a full-color, enlarged page design, this edition offers the most readable, up-to-date, and thorough introduction to the field for biologists. The new "Foundations" section insures that readers have a firm understanding of the technologies that generate the data, as well as the essential statistical and programming tools. Features include special boxes, enhanced use of real examples, and problem sets with answers provided on the book's dedicated website (www.wiley.com/bioinformatics). A glossary and appendix of sample file formats rounds out the book's reader-friendly, 'hands-on' treatment"--

Computational Biology --- Sequence Analysis --- Base Sequence --- Databases, Nucleic Acid --- Databases, Protein --- methods --- Base Sequence. --- Databases, Nucleic Acid. --- Databases, Protein. --- Methods. --- methods. --- Bioinformatics --- Protein Structure Databases --- SwissProt --- Amino Acid Sequence Databases --- Databases, Amino Acid Sequence --- Protein Databases --- Protein Sequence Databases --- SWISS-PROT --- Database, Protein --- Database, Protein Sequence --- Database, Protein Structure --- Databases, Protein Sequence --- Databases, Protein Structure --- Protein Database --- Protein Sequence Database --- Protein Structure Database --- SWISS PROT --- Sequence Database, Protein --- Sequence Databases, Protein --- Structure Database, Protein --- Structure Databases, Protein --- DNA Databanks --- DNA Sequence Databases --- European Molecular Biology Laboratory Nucleotide Sequence Database --- Nucleic Acid Sequence Databases --- RNA Sequence Databases --- DDBJ --- DNA Data Bank of Japan --- DNA Data Banks --- DNA Databases --- Databases, DNA --- Databases, DNA Sequence --- Databases, Nucleic Acid Sequence --- Databases, RNA --- Databases, RNA Sequence --- EMBL Nucleotide Sequence Database --- GenBank --- Nucleic Acid Databases --- RNA Databases --- Bank, DNA Data --- Banks, DNA Data --- DNA Data Bank --- DNA Databank --- DNA Database --- DNA Sequence Database --- Data Bank, DNA --- Data Banks, DNA --- Databank, DNA --- Databanks, DNA --- Database, DNA --- Database, DNA Sequence --- Database, Nucleic Acid --- Database, RNA --- Database, RNA Sequence --- Nucleic Acid Database --- RNA Database --- RNA Sequence Database --- Sequence Database, DNA --- Sequence Database, RNA --- Sequence Databases, DNA --- Sequence Databases, RNA --- Genetic Testing --- Gene Library --- DNA Fingerprinting --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Genes --- Nucleotides --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Data processing