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Quatrième de couverture : "Et si c'était un médicament ? De nombreux symptômes buccaux peuvent être induits par des médicaments. L'imputabilité potentielle d'un traitement reste néanmoins trop rarement évoquée en pratique clinique. Toxicités buccales des médicaments est un guide pratique destiné au clinicien, afin de l'aider dans son exercice quotidien. Cet ouvrage collectif, réalisé par des spécialistes reconnus du domaine, s'adresse à un public élargi : chirurgiens-dentistes, chirurgiens oraux et maxilllo-faciaux, stomatologues, ORL, dermatologues, médecins généralistes ou pharmaciens. Les différentes lésions élémentaires rencontrées en clinique ont été détaillées : réactions lichénoïdes, pigmentations secondaires, accroissements gingivaux, ulcérations muqueuses, xérostomie, dysgueusie. Pour chacun de ces symptômes, les principaux médicaments incriminés (à la fois par Dénomination commune internationale et par noms commerciaux), les hypothèses physiopathologiques, les diagnostics différentiels indispensables à évoquer et les principes de leur prise en charge sont décrits. Cet ouvrage, illustré par de nombreuses photographies cliniques, est enrichi de tableaux, d'arbres décisionnels et de points synthétiques qui permettent une approche simplifiée pour le praticien. Enfin, une place privilégiée a été faite à la toxicité des nouvelles classes pharmacologiques, comme les thérapies ciblées anticancéreuses ou les nouveaux antithrombotiques."

Pharmaceutical Preparations --- Drug-Related Side Effects and Adverse Reactions --- toxicity --- Médicaments --- Bouche --- Effets secondaires indésirables des médicaments --- Maladies de la bouche. --- Préparations pharmaceutiques --- Effets secondaires. --- Maladies. --- Toxicologie. --- diagnostic. --- toxicité. --- Pharmaceutical preparations --- Drug-related side effects and adverse reactions --- Mouth diseases --- Drug Toxicity. --- Mouth Diseases. --- Drug-Related Side Effects and Adverse Reactions. --- Médicaments --- Pharmaceutical Preparations - toxicity --- Mouth Diseases

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Outside back cover : "Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry. Includes expanded coverage of pharmacokinetics fundamentals and effects. Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods"

Pharmaceutical chemistry. --- Drugs --- Drug development. --- Structure-activity relationships. --- Design. --- Drug Design --- Drug Evaluation, Preclinical --- Drug-Related Side Effects and Adverse Reactions --- Pharmaceutical Preparations --- Pharmacokinetics --- Structure-Activity Relationship --- Drug design --- Pharmaceutical design --- Drug development --- Development of drugs --- New drug development --- Pharmacology --- Pharmacy --- Structure-activity relationship (Pharmacology) --- Pharmaceutical chemistry --- Structure-activity relationships (Biochemistry) --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Development