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Metabolism --- Disorders --- Genetic aspects. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology

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Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Cellular biology. --- Metabolism. --- Metabolic engineering. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- computational methods --- Metabolic Engineering --- Cellular metabolism --- Metabolic Regulation --- modeling formalisms --- Systems Biology --- phenotype simulation --- Mathematical Models --- Cytology.

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This timely volume provides an overview to the causes, effects on systems and clinical approaches of metabolic acidosis.  Beginning with a basic understanding of the physiology, pathophysiology and development of this disease, subsequent chapters cover the characteristics and context of the processes that can cause it and a thorough presentation of management strategies.  Recommended treatments include those carried out by the health care provider as well as the individual patient, such as dietary management.  Clinicians and healthcare professionals will find the tools needed to recognize, work up and manage patients with metabolic acidosis in this practical and concise resource.

Personal health and hygiene. --- Urology & Nephrology --- Medicine --- Health & Biological Sciences --- Acidosis. --- Metabolism --- Disorders --- Diagnosis. --- Treatment. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Acid-base imbalances --- Biochemistry --- Physiology --- Nephrology. --- Metabolic diseases. --- Metabolic Diseases. --- Clinical Nutrition. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Internal medicine --- Kidneys --- Clinical nutrition. --- Clinical nutrition --- Diet --- Diet and disease --- Dietotherapy --- Food --- Medical nutrition therapy --- MNT (Medical nutrition therapy) --- Nutrition therapy --- Dietetics --- Therapeutics, Physiological --- Therapeutic use

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This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Medicine. --- Immunology. --- Oncology. --- Biochemistry. --- Cell biology. --- Medicine & Public Health. --- Biochemistry, general. --- Cell Biology. --- Cancer --- Metabolism. --- Endocrine aspects. --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Cancer endocrinology --- Hormonal aspects of cancer --- Hormonal aspects --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Tumors --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Composition --- Biochemistry --- Physiology --- Oncology  . --- Cytology.

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This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Drug development. --- Pharmacology. --- Pharmacy --- Clinical biochemistry. --- Research. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Pharmaceutical research --- Drug effects --- Medical pharmacology --- Development of drugs --- Drugs --- New drug development --- Development --- Medicine. --- Medical biochemistry. --- Pharmacy. --- Metabolism. --- Biomedicine. --- Pharmacology/Toxicology. --- Drug Safety and Pharmacovigilance. --- Medical Biochemistry. --- Metabolomics. --- Medical sciences --- Chemicals --- Chemotherapy --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Chemistry --- Medicine --- Materia medica --- Pharmacology --- Pathology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Physiological effect --- Toxicology. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Poisoning --- Poisons --- Composition --- Toxicology