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Le domaine de la production de froid se trouve dans un contexte de rapide évolution technologique et réglementaire liée notamment à la F-gaz. Cette troisième édition refondue intègre de précieuses informations sur les solutions émergentes basées sur les fluides naturels (CO2, ammoniac et hydrocarbures) ainsi que sur les nouveaux HFO. Le lecteur y trouvera toutes les données lui permettant de trouver une solution à la pointe de l'état de l'art pour des applications allant du froid industriel à la pompe à chaleur en passant par le froid commercial ou domestique et les transports frigorifiques. Cet ouvrage constitue un outil de travail indispensable aux ingénieurs frigoristes (conception, installation et maintenance) en froid et climatisation et en génie énergétique. Il est également la référence des élèves-ingénieurs et étudiants du domaine. [Quatrième de couverture]

Refrigeration and refrigerating machinery --- Réfrigération et appareils frigorifiques. --- Réfrigération et appareils frigorifiques.

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The purpose of this Volume is to provide a collection of recent contributions in the field of heat and mass transfer in porous media. It includes a set of new developments in the field of basic and applied research work on the physical and chemical aspects of heat and mass transfer phenomena in a porous medium domain, as well as related material properties and their measurements. This volume contents include both theoretical and experimental developments, providing a self-contained major reference that is appealing to both the scientists and the engineers.The topics that will be presented in t

Heat --- Heat exchangers --- Chemical engineering --- Refrigeration and refrigerating machinery --- Transmission --- Fluid dynamics --- Equipment and supplies

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"Object Lessons is a series of short, beautifully designed books about the hidden lives of ordinary things.Have you ever thought seriously about your refrigerator? The box humming in the background actually displays who you are and the society in which you live. This book examines the past, present, and future of the electric household refrigerator with an eye towards preventing its users from ever taking it for granted again. No mere container for cold Cokes and celery stalks, the refrigerator is actually more like a mirror-and what it reflects is chilling indeed.Object Lessons is published in partnership with an essay series in the The Atlantic"--

Food --- LITERARY CRITICISM / Semiotics & Theory. --- PHILOSOPHY / Aesthetics. --- Refrigeration and refrigerating machinery --- SOCIAL SCIENCE / Anthropology / Cultural. --- Cooling

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Ventilation --- Air conditioning --- Refrigeration and refrigerating machinery --- Heating --- Equipment and supplies

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This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch lyophilized biologics or vaccine products, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fusion), complex biologics (e.g., antibody drug conjugates,  PEGylated proteins) and vaccines (e.g., recombinant protein based). The authors adeptly guide you through everything you need to know, from biophysical and chemical stability considerations of proteins, to critical assessment during process scale-up, technology transfer, packaging, alternate drying and device selection for a successful process validation, regulatory submission and launch of a stable, safe and effective product. Lyophilized Biologics and Vaccines: Modality-Based Approaches serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: Provides recent understanding of heterogeneity of protein environment in frozen systems, buffer stabilization, instrumental analysis and controlled ice nucleation technology Details product development strategies based on diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics Recent updates on quality-by-design and process analytical technology approaches, illustrated by case studies and FDA perspective Provides the latest account of alternate drying technologies including spray drying and bulk freeze-drying Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals.  Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development and commercial manufacturing.   Dushyant B. Varshney, Ph.D., has made significant contributions in manufacturing science and technology, due diligence, tech transfer, product and process development (including lyophilization), quality-by-design and process analytical technologies for biologics, vaccines and small molecules. He is currently a Director of Manufacturing Assessment, MS&T at Hospira Inc.   Manmohan Singh, Ph.D., is a well-known expert in the area of vaccine formulations and adjuvant research and has been working in vaccine R&D for the last 20 years. He is currently the Head of Global Drug Product Development at Novartis Vaccines and Diagnostics in Holly Springs, NC.

Biomedicine. --- Vaccine. --- Antibodies. --- Pharmaceutical Sciences/Technology. --- Medicine. --- Monoclonal antibodies. --- Vaccines. --- Pharmaceutical technology. --- Médecine --- Anticorps monoclonaux --- Vaccins --- Techniques pharmaceutiques --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Pharmacy, Therapeutics, & Pharmacology --- Freeze-drying. --- Frozen drugs. --- Cryopharmacy --- Drugs --- Drugs, Frozen --- Freezing of drugs --- Lyophilization --- Freezing --- Cryobiology --- Drying apparatus --- Refrigeration and refrigerating machinery --- Sublimation (Chemistry) --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Biologicals --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins