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This work is a compiled catalogue of such findings, where several NGS technologies ranging from the genomics, transcriptomics, metagenomics, single cell genomics, QTL, patho-genomics and patho-transcriptomics have been applied to delineate the mystery of the associated mutations, biological pathway transitions, transcriptional fluxes and patterns of host associated or adaptations to certain climatic conditions. The aims and scope of this book focuses more on the biological underpinning to initiate the cross-talks across the traits acquired or lost during the course of evolution. The structured framework of the present volume provides the applicative point of view of the NGS technologies and demonstrates the conceptual way of linking the experimentation to the NGS technologies, to aid in researchers to place their biological hypothesis in a larger context.

Life Sciences. --- Plant Breeding/Biotechnology. --- Plant Genetics & Genomics. --- Plant Physiology. --- Life sciences. --- Plant breeding. --- Plant physiology. --- Sciences de la vie --- Plantes --- Physiologie végétale --- Amélioration --- Genetics -- Technique. --- Nucleotide sequence. --- Agriculture --- Earth & Environmental Sciences --- Agriculture - General --- Plant Sciences --- Genetics --- Technique. --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Plant genetics. --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Analysis --- Plant Genetics and Genomics. --- Botany --- Plants --- Physiology --- Crops --- Breeding

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The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects.   Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.  .

Biomedicine. --- Immunology. --- Systems Biology. --- Proteomics. --- Cell Biology. --- Medicine. --- Biological models. --- Cytology. --- Médecine --- Immunologie --- Protéomique --- Modèles biologiques --- Cytologie --- Immunoinformatics. --- Nucleotide sequence. --- Systems biology. --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Analysis, Nucleic acid sequence --- Analysis, Nucleotide sequence --- Base sequence (Nucleic acids) --- DNA sequence --- Nucleic acid sequence analysis --- Nucleotide sequence analysis --- RNA sequence --- Sequence, Nucleotide --- Computational immunology --- Immunological informatics --- Cell biology. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Nucleic acids --- Nucleotides --- Sequence alignment (Bioinformatics) --- Immunology --- Analysis --- Data processing --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Proteins --- Models, Biological --- Immunobiology --- Life sciences --- Serology