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ISBN: 9175193035 Year: 2014 Publisher: Linköping, Sweden : Linköping University,
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Killer cells --- T cells --- Research.
Book
ISBN: 1493913115 1493913107 Year: 2014 Publisher: New York, NY : Springer New York : Imprint: Springer,
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Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease.
Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Immunology. --- Monoclonal antibodies. --- Microbiology. --- Antibodies. --- Medical Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Immunobiology --- Life sciences --- Serology --- Medical microbiology. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins
Book
ISBN: 9401788812 9401788804 1322044058 Year: 2014 Publisher: Dordrecht : Springer Netherlands : Imprint: Springer,
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This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein superfamily that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC superfamily are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes. The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different superfamily members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function. .
Membrane proteins. --- Cell-mediated cytotoxicity. --- Membranes (Biology) --- Proteins --- Cytotoxicity, Cell-mediated --- Cell death --- Killer cells --- Medicine. --- Chemistry. --- Entomology. --- Pharmacy. --- Biomedicine general. --- Medicine/Public Health, general. --- Science, Humanities and Social Sciences, multidisciplinary. --- Chemistry/Food Science, general. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Insects --- Zoology --- Physical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Biology --- Medical sciences. --- Social sciences. --- Humanities. --- Invertebrates. --- Biomedical Research. --- Health Sciences. --- Humanities and Social Sciences. --- Invertebrate Zoology. --- Research. --- Invertebrata --- Animals --- Learning and scholarship --- Classical education --- Behavioral sciences --- Human sciences --- Sciences, Social --- Social science --- Social studies --- Civilization --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical --- Biological research --- Biomedical research
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