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For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications. Translational Stem Cell Research is broken into ten sections. It opens with an overview of the latest in stem cell research, focusing on specific diseases and the treatment of burn victims. Part II discusses the issues involved in the many steps from bench to bedside, ranging from first research in vitro to clinical trials. Part III covers scientific, regulatory and ethical challenges to basic research, and Part IV details issues regarding stem cell banks. Part V explores ethical, economic and strategic issues involved in collaboration between universities and industry, and Part VI addresses legal problems raised by patents on human stem-cell based inventions plus the extent to which there can be technological solutions to a moral dilemma. Part VII presents imaginative ways of communicating research to the general public and how to create conditions for a constructive dialogue. Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees. The book closes with a look into the future of translational stem cell research and stem cell-based therapeutic applications.
Histology. Cytology --- stamcellen --- stamceltransplantatie
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There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.
Histology. Cytology --- stamcellen --- stamceltransplantatie
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This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly existing conservative practices. This volume is a collection of authoritative reviews. In the introductory part we define the field (intracellular delivery). Then, we first we cover fundamental routes of nanodelivery devices cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; all at academic and applied levels. Following is dedicated to enhancing delivery via special targeting motifs. Second, we introduce different types of intracellular nanodelivery devices (their chemistry, although the coverage is far from complete) and ways of producing these different devices. Third, we put special emphasis on particular disease states and on other biomedical applications. Diagnostic and sensing is also included. The intracellular delivery/therapy is a very pregnant topic which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is a great potential for targeted delivery with improved localized delivery and efficacy.
Histology. Cytology --- cytologie --- histologie
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Histology. Cytology --- stamcellen --- stamceltransplantatie
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Histology. Cytology --- stamcellen --- stamceltransplantatie
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Histology. Cytology --- cytologie --- histologie
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Une révolution se produit actuellement en biologie. Les êtres vivants ne sont pas gouvernés par un programme génétique omnipotent. Il est maintenant clairement démontré que le hasard se niche au coeur des organismes, dans le fonctionnement des gènes et des cellules, et y joue un rôle encore largement sous-exploré. Alors que pendant longtemps, la biologie a été dominée par des théories finalistes puis « ?déterministes? », les résultats expérimentaux obtenus ces toutes dernières années annoncent un changement de perspective radical. La nouvelle biologie, par son caractère probabiliste, rendra caduque l'idée même de programme et de déterminisme génétique – conception communément qualifiée de thèse du « tout génétique » – forgée à la suite de ce qu'il a été convenu d'appeler le « dogme central de la biologie moléculaire » (Francis Crick, 1958). Mais, cette nouvelle biologie ne doit pas être comprise comme une négation des acquis antérieurs de la biologie moléculaire. Bien au contraire, elle constitue une extension de la conception physico-chimique du vivant. Inévitablement, elle aura également de profondes conséquences philosophiques. En effet, ce n'est pas seulement le finalisme – religieux ou immanent – qui est de facto évacué, mais c'est encore la conception cartésienne de l'animal-machine qui doit être abandonnée. Si l'homme est une machine, il est aussi un homme-aléatoire !
Cytogenetics. --- Genetics. --- Cytology. --- Genomics.
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