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Drugs of abuse consumption is a real daily concern for our societies.
Authorities who penalyze those who drive under the influence of illicit drugs, but also clinical and forensic toxicology, encourage laboratories using an appropriate method for the detection and quantification of these analytes in different biological matrices.
That’s why we developed a method for the simultaneous quantification of amphetamines, opiates, cocaine and metabolites, using a combination of HPLC and tandem mass spectrometry in positive electrospray ionisation. Quantification is performed with Multiple Reaction Monitoring (MRM) transitions of the studied drugs and their deuterated analogues used as internal standards. A validation study was carried-out for plasma, blood and urine. Precision, accuracy, LOD, LOQ, linearity, extraction yield, stability parameters and ion suppression tests were investigated in each biological matrix.
The analytical validation showed results corresponding to our wishes and our method was also tested for vitreous humor. Results showed correlations and discordances between blood levels and those obtained in vitreous humor. Vitreous humor seems to be a good qualitative matrix to be investigated when blood sample is not available. However, for the quantitative aspects, others phenomenons like drug’s instability in blood, or post-mortem redistribution , are contributing to discordance observed between blood and vitreous humor La consommation de stupéfiants constitue actuellement un réel problème de société. Les autorités qui pénalisent ceux qui conduisent sous l’influence de substance illicites, mais aussi la toxicologie clinique et médico-légale, demandent aux laboratoires d’utiliser une méthode appropriée pour la détection et la quantification de ces analytes dans différents milieux biologiques.
C’est pourquoi nous avons développé une méthode pour la quantification simultanée des amphétamines, des opiacés, de la cocaïne et de ses métabolites, utilisant un couplage HPLC et spectrométrie de masse tandem en ionisation par électrospray positive.
La quantification est réalisée via les transitions MRM des substances étudiées et de leurs homologues deutérés utilisés comme standards internes.
Une validation analytique fut réalisée pour le plasma, le sang et l’urine.
La précision, l’exactitude, la LOD, la LOQ, la linéarité, le rendement d’extraction, la stabilité et des tests de suppression d’ions furent investigués dans chaque matrice biologique.
La validation a montré des résultats correspondants à nos espérances et la méthodologie fut appliquée au liquide oculaire. Les résultats ont montré des similitudes et des discordances entre es taux sanguins et ceux obtenus dans l’humeur vitrée.
Le vitré semble être un bon prélèvement qualitatif à investiguer lorsqu’il n’y a pas d’échantillon sanguin disponible.
Cependant, d’un point de vue quantitatif, d’autres phénomènes comme l’instabilité des molécules dans le sang ou la redistribution post-mortem, contribuent certainement à alimenter ces différences observées entre sang et vitré

Narcotics --- Chromatography, Liquid --- Mass Spectrometry --- Amphetamine --- N-Methyl-3,4-methylenedioxyamphetamine

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Drug traffic. --- Human smuggling. --- Prostitution. --- Illegal arms transfers. --- Organized crime. --- Globalization --- Crime syndicates --- Organised crime --- Crime --- Arms smuggling --- Arms trafficking --- Contraband arms traffic --- Gun running --- Gunrunning --- Illegal arms trafficking --- International illicit arms sales --- Arms transfers --- Female prostitution --- Hustling (Prostitution) --- Prostitution, Female --- Sex trade (Prostitution) --- Sex work (Prostitution) --- Street prostitution --- Trade, Sex (Prostitution) --- White slave traffic --- White slavery --- Work, Sex (Prostitution) --- Sex-oriented businesses --- Brothels --- Pimps --- Procuresses --- Red-light districts --- Sex crimes --- Immigrant smuggling --- Migrant smuggling --- People smuggling --- Smuggling --- Illegal aliens --- Drug dealing --- Drug production, Illicit --- Drug smuggling --- Drug trade, Illicit --- Drug trafficking --- Drugs --- Illicit drug production --- Illicit drug trade --- Narcotic trade --- Narcotic traffic --- Narcotic trafficking --- Smuggling of drugs --- Smuggling of narcotics --- Traffic, Drug --- Trafficking in drugs --- Trafficking in narcotics --- Drug abuse and crime --- Narco-terrorism --- Economic aspects. --- Prices and sale --- Drogues --- Trafic de migrants --- Prostitution --- Armes --- Crime organisé --- Mondialisation --- Trafic --- Aspect économique --- Illegal immigration --- Sex work

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Drug abuse --- Drug control --- Drugs --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Drug enforcement --- Drug law enforcement --- Drug policy --- Drug traffic --- Drug traffic control --- Narcotics, Control of --- War on drugs --- Vice control --- Drug use --- Recreational drug use --- Substance abuse --- Prevention --- Law and legislation --- Government policy --- Prevention. --- Drug control - Europe. --- Drug abuse - Europe - Prevention. --- Drugs - Law and legislation - Europe.

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