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Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.

Receptors --- Immunosuppressive Agents. --- Lymphocyte Activation. --- Immunologic. --- Immune System Processes --- Immunity, Cellular --- Immunologic Tests --- Receptors, Cell Surface --- Immunologic Factors --- Amino Acids, Aromatic --- Adaptive Immunity --- Immune System Phenomena --- Membrane Proteins --- Physiological Effects of Drugs --- Amino Acids, Cyclic --- Immunologic Techniques --- Laboratory Techniques and Procedures --- Investigative Techniques --- Immunity --- Amino Acids --- Proteins --- Diagnosis --- Phenomena and Processes --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Chemicals and Drugs --- Immunosuppressive Agents --- Lymphocyte Activation --- Tyrosine --- Receptors, Immunologic --- Immunology. --- Cell biology. --- Cancer research. --- Cell Biology. --- Cancer Research. --- Cancer research --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Cell proliferation. --- Cell renewal --- Cellular proliferation --- Cell cycle --- Cell division --- Cell populations --- Growth