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Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.

Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Oncology

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A wide range of ongoing research in the areas of controller design and information engineering reveals that the pace of technological change in this domain seems to be accelerating. The primary focus is on futuristic segments ranging from robotics, genomics to chemical feedstock and electrical storage. The main objective of this special issue was to provide a forum for researchers and practitioners to exchange their latest theoretical and technological achievements and to identify critical issues and challenges for future investigation on topics regarding advanced automation and control techniques based on information system technologies.

fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system --- n/a

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The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

minerals --- cancer treatment --- chitosan --- n/a --- neurodegeneration --- antioxidant activity --- senescence --- tumor proliferation --- nanoparticles --- antimicrobial agents --- oxidative metabolites --- drug discovery --- Akt/mTOR signaling --- micronutrients --- ulcerative colitis --- transmission electron microscopy --- metabolic reprogramming --- curcumin --- death receptor --- chaperone-mediated autophagy --- wound healing --- brain ischemia --- autophagy --- Alzheimer’s disease --- genes --- transthyretin --- inflammatory bowel disease --- cellular pathway --- centrifugal partition chromatography --- nutrition --- amyloid --- Curcuma longa --- protein aggregation --- supportive care --- IL-17 --- senolytics --- complementary medicine --- macronutrients --- structure activity relationship --- gastroprotection --- Zingiberaceae --- anti-inflamation --- TLC bioautography --- microbiota --- glioblastoma multiforme --- amyloidosis --- SHMT2 --- antioxidants --- silica --- apoptosis --- reflux esophagitis --- gastric ulcer --- TLC-MS --- anti-cancer --- anticancer --- ImageJ --- anti-tumor --- delivery system --- wound --- Helicobacter pylori --- direct protein binding --- protein misfolding --- tumor growth --- diet --- Crohn’s disease --- hydrostatic counter-current chromatography --- ageing --- renal cell cancer --- gastric cancer --- amino-acids --- STAT3 --- mechanism of action --- inflamm-aging --- mitophagy --- necrotizing enterocolitis --- cell cycling --- vitamins --- turmeric tuber --- cancer --- tau protein --- Alzheimer's disease --- Crohn's disease

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Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2–Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering --- n/a --- the Bcl-2-Beclin 1 complex