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RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-target effects such as the silencing of unwanted genes and activation of innate immunity. In siRNA and miRNA Gene Silencing: From Bench to Bedside, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods to minimize siRNA's unwanted effects and promote successful use in patients. As part of the highly successful Methods in Molecular Biology™ series, the chapters focus on their respective subjects with easy-to-use, up-to-date information, including several step-by-step laboratory protocols on topics such as new delivery formulations and strategies with promising applications in vitro and in vivo, validated therapeutic target genes, and components of miRNA function, biogenesis, and interference with virus infection. Comprehensive and cutting-edge, siRNA and miRNA Gene Silencing: From Bench to Bedside offers an excellent collection of chapters to aid all those with an interest in RNAi, gene regulation, and new therapies.

RNA, Small Interfering --- MicroRNAs --- Gene Silencing. --- RNA, Small Interfering. --- Small interfering RNA --- Gene silencing. --- Petits ARN interférents --- Inactivation génétique --- therapeutic use. --- MicroRNA. --- Small interfering RNA. --- Antisense RNA. --- Gene silencing --- RNA, Antisense --- RNA, Small Untranslated --- Epigenesis, Genetic --- RNA --- Antisense Elements (Genetics) --- RNA, Untranslated --- Gene Expression Regulation --- Gene Silencing --- Nucleic Acids, Nucleotides, and Nucleosides --- Genetic Processes --- Nucleic Acids --- Chemicals and Drugs --- Genetic Phenomena --- Phenomena and Processes --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Petits ARN interférents --- Inactivation génétique --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Acids, Nucleic --- Gene Inactivation --- Inactivation, Gene --- Silencing, Gene --- Micro RNA --- MicroRNA --- Primary MicroRNA --- Primary miRNA --- miRNAs --- pre-miRNA --- pri-miRNA --- RNA, Small Temporal --- Small Temporal RNA --- miRNA --- stRNA --- MicroRNA, Primary --- RNA, Micro --- Temporal RNA, Small --- miRNA, Primary --- pre miRNA --- pri miRNA --- Short Hairpin RNA --- Short Interfering RNA --- Small Hairpin RNA --- Small Interfering RNA --- piRNA --- scnRNA --- shRNA --- tasiRNA --- Piwi-Interacting RNA --- RNA, Piwi-Interacting --- RNA, Scan --- Repeat-Associated siRNA --- Scan RNA --- Small Scan RNA --- Trans-Acting siRNA --- siRNA --- siRNA, Repeat-Associated --- siRNA, Trans-Acting --- Hairpin RNA, Short --- Hairpin RNA, Small --- Interfering RNA, Short --- Interfering RNA, Small --- Piwi Interacting RNA --- RNA, Piwi Interacting --- RNA, Short Hairpin --- RNA, Short Interfering --- RNA, Small Hairpin --- RNA, Small Scan --- Repeat Associated siRNA --- Scan RNA, Small --- Trans Acting siRNA --- siRNA, Repeat Associated --- siRNA, Trans Acting --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Noncoding RNA --- RNA, Non-Coding --- RNA, Non-Peptide-Coding --- RNA, Non-Protein-Coding --- RNA, Noncoding --- RNA, Nontranslated --- npcRNA --- Non-Coding RNA --- Non-Peptide-Coding RNA --- Non-Protein-Coding RNA --- Nontranslated RNA --- RNA, Non Coding --- RNA, Non Peptide Coding --- RNA, Non Protein Coding --- Untranslated RNA --- Anti-Sense Elements --- Anti-Sense Probes --- Antisense Probes --- Anti Sense Elements --- Anti Sense Probes --- Elements, Anti-Sense --- Probes, Anti-Sense --- Probes, Antisense --- Gene Products, RNA --- Non-Polyadenylated RNA --- RNA, Non-Polyadenylated --- Ribonucleic Acid --- Acid, Ribonucleic --- Non Polyadenylated RNA --- RNA Gene Products --- RNA, Non Polyadenylated --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Short Noncoding RNA --- Small Non-Coding RNA --- Small Non-Messenger RNA --- Small Non-Protein-Coding RNA --- Small Noncoding RNA --- Small Untranslated RNA --- sncRNA --- sncRNAs --- Non-Coding RNA, Small --- Non-Messenger RNA, Small --- Non-Protein-Coding RNA, Small --- Noncoding RNA, Short --- Noncoding RNA, Small --- RNA, Short Noncoding --- RNA, Small Non-Coding --- RNA, Small Non-Messenger --- RNA, Small Non-Protein-Coding --- RNA, Small Noncoding --- Small Non Coding RNA --- Small Non Messenger RNA --- Small Non Protein Coding RNA --- Untranslated RNA, Small --- Anti-Sense RNA --- Antisense RNA --- Anti Sense RNA --- RNA, Anti-Sense --- Gene inactivation --- Complementary RNA --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Small temporal RNA --- stRNA (Small temporal RNA) --- Biochemistry. --- Human genetics. --- Gene expression. --- Biochemistry, general. --- Human Genetics. --- Gene Expression. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Composition --- Expression