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Gene regulatory networks play a vital role in organismal development and function by controlling gene expression. With the availability of complete genome sequences, several novel experimental and computational approaches have recently been developed which promise to significantly enhance our ability to comprehensively characterize these regulatory networks by enabling the identification of respectively their genomic or regulatory state components, or the interactions between these two in unprecedented detail. Divided into five convenient sections, Gene Regulatory Networks: Methods and Protocols details how each of these approaches contributes to a more thorough understanding of the composition and function of gene regulatory networks, while providing a comprehensive protocol on how to implement them in the laboratory. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Gene Regulatory Networks: Methods and Protocols aims to provide novices and experienced researchers alike with a comprehensive and timely toolkit to study gene regulatory networks from the point of data generation to processing, visualization, and modeling.

Gene expression --- Genetic regulation --- Genetic regulation. --- Genregulation. --- Methode. --- Netzwerk. --- Gene Regulatory Networks --- Gene Expression Regulation --- Gene Expression --- Transcription Factors --- Simulation methods. --- Genetic Processes --- Regulatory Sequences, Nucleic Acid --- Publication Formats --- Proteins --- Publication Characteristics --- Genetic Phenomena --- Base Sequence --- Amino Acids, Peptides, and Proteins --- Genetic Structures --- Phenomena and Processes --- Chemicals and Drugs --- Laboratory Manuals --- Biology --- Health & Biological Sciences --- Biophysics --- Genetics --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Expression, Gene --- Expressions, Gene --- Gene Expressions --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Gene Module --- Gene Circuits --- Gene Modules --- Gene Networks --- Transcriptional Networks --- Circuit, Gene --- Circuits, Gene --- Gene Circuit --- Gene Network --- Gene Regulatory Network --- Module, Gene --- Modules, Gene --- Network, Gene --- Network, Gene Regulatory --- Network, Transcriptional --- Networks, Gene --- Networks, Gene Regulatory --- Networks, Transcriptional --- Regulatory Network, Gene --- Regulatory Networks, Gene --- Transcriptional Network --- Genetic Structure --- Structure, Genetic --- Structures, Genetic --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Region, Regulatory --- Regions, Regulatory --- Regulator Regions, Nucleic Acid --- Regulatory Region --- Regulatory Regions --- Nucleic Acid Regulatory Sequences --- Regulatory Regions, Nucleic Acid (Genetics) --- Genes --- Gene expression regulation --- Gene regulation --- Expression --- Regulation --- Medicine. --- Human genetics. --- Gene expression. --- Biomedicine. --- Human Genetics. --- Gene Expression. --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians