Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system.

Immunology. --- Cytokines. --- Cytokines and Growth Factors. --- Cellular immunity --- Immune response --- Immunobiology --- Life sciences --- Serology --- Regulation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.

Cancer --- Cytokines --- Chemotherapy. --- Therapeutic use. --- Antineoplastic agents --- Treatment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Recent studies have discovered new known and characterized cytokines, allowing for advancement in miniaturization of micro-analytical methods as well as the extensive development of bio-informatics and nanotechnology.  These advancements have allowed researchers to  reduces sample sizes making for more accurate determinations then previously possible. In Cytokine Protocols: Second Edition, expert researchers in the field detail many of the methods which are now commonly used to study cytokines. These methods and techniques for studying cytokines include historical importance and the importance of researchers using bioassay, quantification, and characterization of cytokine related RNAs,  posttranscriptional modifications of RNA, either naturally or artificially, and observations at the protein level. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.   Authoritative and practical, Cytokine Protocols: Second Edition seeks to aid scientists in furthering the crucially important advancement of cytokine research.

Cytology. --- Cytokines. --- Cell Biology. --- Cytokines and Growth Factors. --- Cellular immunity --- Immune response --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Regulation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cytokines --- -Cytokines --- -Cellular immunity --- Immune response --- Congresses --- Therapeutic use --- -Testing --- -Congresses --- Regulation --- Congresses. --- Testing --- Therapeutic use&delete& --- Testing&delete& --- Cellular immunity

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.

Chemokines --- Virus diseases --- Pathophysiology. --- Pathogenesis. --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Cytokines --- Inflammation --- Peptides --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Mediators --- Microbiology. --- Medical Microbiology. --- Microbial biology --- Biology --- Microorganisms --- Medical microbiology.