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This dissertation by Veronica Sandgren focuses on the design and synthesis of inhibitors targeting BACE-1, an aspartic protease involved in Alzheimer's disease. The research aims to develop therapeutic agents by creating various inhibitors that can prevent the formation of amyloid-β peptides, which are associated with the pathology of Alzheimer's. The thesis discusses the structure-activity relationship of synthesized inhibitors, including linear, cyclic, and macrocyclic compounds. It also examines the challenges of improving cell permeability while maintaining potency. The intended audience is researchers and professionals in biochemistry and pharmacology, particularly those working on Alzheimer's treatments.

Protease inhibitors. --- Alzheimer's disease.

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ALZHEIMER DISEASE --- ALZHEIMER DISEASE --- PEPTIDE PEPTIDOHYDROLASES --- PROTEASE INHIBITORS --- ETIOLOGY --- PHYSIOPATHOLOGY --- ALZHEIMER DISEASE --- ALZHEIMER DISEASE --- PEPTIDE PEPTIDOHYDROLASES --- PROTEASE INHIBITORS --- ETIOLOGY --- PHYSIOPATHOLOGY

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Botany & plant sciences --- Plant Proteases --- Protease Inhibitors --- Protease Substrates --- Proteolysis --- Protein Turnover --- Plant Proteases --- Protease Inhibitors --- Protease Substrates --- Proteolysis --- Protein Turnover

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HIV PROTEASE --- HIV PROTEASE INHIBITORS --- HEPATITIS C-LIKE VIRUSES --- HERPESVIRIDAE --- PICORNAVIRIDAE --- CANDIDA --- MALARIA --- CHAGAS DISEASE --- PLANT VIRUSES --- INFLUENZA --- PARAMYXOVIRUS --- ANALYSIS --- HIV PROTEASE --- HIV PROTEASE INHIBITORS --- HEPATITIS C-LIKE VIRUSES --- HERPESVIRIDAE --- PICORNAVIRIDAE --- CANDIDA --- MALARIA --- CHAGAS DISEASE --- PLANT VIRUSES --- INFLUENZA --- PARAMYXOVIRUS --- ANALYSIS

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Virus inhibitors --- Virus diseases --- Antiviral agents --- Virus Inhibitors --- Virus Diseases --- Antiviral Agents --- immunology --- Antiviral Agents. --- Virus research --- Agents antiviraux --- Antiviraux --- Maladies à virus --- Virus --- Antiviral agents. --- Virus diseases. --- Virus inhibitors. --- immunology. --- Périodiques. --- Inhibiteurs --- Immunologie --- Antiviruses --- Viral diseases --- Viral infections --- Virus infections --- Antiviral drugs --- Antivirals --- Antiviral Drugs --- Agents, Antiviral --- Drugs, Antiviral --- Viruses --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Anti-infective agents --- Interferon Inducers --- Virus Inactivation --- Chemotherapy --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Virus Diseases. --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Antiviraux. --- Periodicals. --- Viral Protease Inhibitors. --- Inhibitor of Viral Protease --- Virus Protease Inhibitors --- Inhibitors, Viral Protease --- Inhibitors, Virus Protease --- Protease Inhibitor, Viral --- Protease Inhibitors, Viral --- Protease Inhibitors, Virus --- Viral Protease Inhibitor --- Viral Proteases --- antagonists & inhibitors --- Viral Inactivation --- Inactivation, Viral --- Inactivation, Virus