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"Physiologically based pharmacokinetic modeling (PBPK) is an emerging field with increasing importance in drug discovery and development. It has become a common tool for most pharmaceutical scientists. This is the only book of its kind to serve the rapidly growing PBPK user community, developing principles from basics in clear, concise language. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. The new edition provides stronger emphasis on applications and relevant case studies, along with a companion website with datasets, covering many key developments in the field of PBPK modelling and simulations since the first edition's publication in 2012. In addition to revised chapters and improved figures and tables, the author adds a chapter on model-informed drug development and an entire 3rd section of case studies in different application areas to facilitate use in courses or development workshops"--
Pharmacokinetics. --- Drug Design. --- Models, Biological. --- Pharmacocinétique --- Conception de médicament --- Modèles biologiques
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Biological models. --- Drosophila --- Evolution (Biology). --- Evolution. --- Models --- Animal population --- Phylogeny --- population genetics --- biological development --- Évolution --- evolution --- ecology --- Evolution (Biology) --- Drosophiles --- Evolution (Biologie) --- Modèles biologiques --- Evolution --- evolution. --- Biological models --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Models, Biological --- Biology --- Biological fitness --- Homoplasy --- Natural selection --- Drosophilidae --- Fruit-flies
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Models, Theoretical --- Models, Biological --- Medicine, Experimental --- Biological models --- Biological systems --- Médecine expérimentale --- Modèles biologiques --- Systèmes biologiques --- Periodicals. --- Mathematical models --- Periodicals --- Périodiques --- Modèles mathématiques --- Models, Theoretical. --- Models, Biological. --- Biological models. --- Medicine, Experimental. --- Mathematical models. --- Health Sciences --- General and Others --- computational methods --- mathematical methods --- biomedical computation --- Biosystems --- Systems, Biological --- Biomedicine. --- Mathematics. --- Biology --- System theory --- Systems biology --- Biological Model --- Biological Models --- Model, Biological --- Models, Biologic --- Biologic Model --- Biologic Models --- Model, Biologic --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Computer Simulation --- Systems Theory --- Experimental medicine --- Medicine --- Philosophy --- Research --- Médecine expérimentale --- Modèles biologiques --- Systèmes biologiques --- Human medicine --- Computer. Automation --- Medicina experimental. --- Sistemes biològics. --- Models matemàtics.
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Not only do glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators facilitate the transfer of messages from one cell to another, they also facilitate communication among subcellular organelles. Hot Topics in Neural Membrane Lipidology provides readers with a cutting-edge, comprehensive review of these lipid mediators, their roles and association with neurological disorders, and the future direction of research on the topic. This monograph provides readers with critical data and is particularly accessible to neuroscience graduate students, teachers, and researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in acute neural trauma like stroke, spinal cord trauma, head injury, and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. About the Author: Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. Dr. Farooqui has authored three monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.
Cell membranes. --- Electronic structure --Congresses. --- Membrane lipids. --- Neurons. --- Phospholipases. --- Phospholipids. --- Selenium --Congresses. --- Sphingolipids. --- Tellurium --Congresses. --- Membrane lipids --- Cell membranes --- Neurons --- Sphingolipids --- Phospholipids --- Phospholipases --- Membrane Lipids --- Neurotoxins --- Lipids --- Noxae --- Carboxylic Ester Hydrolases --- Phosphoric Diester Hydrolases --- Esterases --- Toxic Actions --- Chemicals and Drugs --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Enzymes and Coenzymes --- Animal Biochemistry --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Phosphatides --- Nerve cells --- Neurocytes --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- 538.91 <063> --- Biological models --- Modèles biologiques --- Modèles biologiques --- Medicine. --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychopharmacology. --- Biomedicine. --- 538.93 <063> --- 538.91 <063> Structures, including transitions--Congressen --- Structures, including transitions--Congressen --- 538.93 <063> Transport processes (except in quantum liquids and solids)--Congressen --- Transport processes (except in quantum liquids and solids)--Congressen --- Solid state physics --- Sphingosine --- Phosphates --- Cells --- Nervous system --- Membranes (Biology) --- Glycocalyces --- Endocrinology --- Mathematical models --- Data processing --- Endocrinologie --- Modèles mathématiques --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Psychotropic effects --- Diseases --- Neurology .
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