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Merkel Cell Carcinoma is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare – and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world. Features: Comprehensive single-source clinical reference Treatment focus Written for practitioners, with emphasis on clinical relevance and quick retrieval of information Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology International in perspective, with contributors from US and abroad Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters.

Carcinoma, Merkel cell. --- Medicine. --- Merkel cell carcinoma. --- Merkel cell carcinoma --- Medicine --- Neoplasms by Site --- Carcinoma, Neuroendocrine --- Mechanoreceptors --- Neoplasms --- Health Occupations --- Sensory Receptor Cells --- Neuroendocrine Tumors --- Neuroectodermal Tumors --- Neurons, Afferent --- Disciplines and Occupations --- Diseases --- Neurons --- Neoplasms, Germ Cell and Embryonal --- Neoplasms by Histologic Type --- Nervous System --- Anatomy --- Carcinoma, Merkel Cell --- Merkel Cells --- Pathology --- Skin Neoplasms --- Health & Biological Sciences --- Dermatology --- Merkel cells. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Dermatology. --- Oncology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Tumors --- Epithelial cells --- Oncology  . --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Skin --- Excision --- Treatment

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The retina plays a critical role in the organization of the circadian system by synchronizing the brain’s central clock with the external day through transduction of the daily light/dark cycle.  However, the substantial variation in luminance imposed on the retina between day and night also poses a challenge to its role as a sensory tissue – how is it possible to faithfully encode the enormous dynamic range of luminance that can exceed 10 orders of magnitude? The Retina and Circadian Rhythms summarizes the knowledge accumulated over the last 30 years about the organization of the retinal circadian clock in many different species, concentrating on the roles that this circadian system plays in retinal function. About the Series: The Springer Series in Vision Research is a comprehensive update and overview of cutting edge vision research, exploring, in depth, current breakthroughs at a conceptual level. It details the whole visual system, from molecular processes to anatomy, physiology and behavior and covers both invertebrate and vertebrate organisms from terrestrial and aquatic habitats. Each book in the Series is aimed at all individuals with interests in vision including advanced graduate students, post-doctoral researchers, established vision scientists and clinical investigators.The series editors are N. Justin Marshall, Queensland Brain Institute, The University of Queensland, Australia and Shaun P. Collin, Neuroecology Group within the School of Animal Biology and the Oceans Institute at the University of Western Australia.

Bipolar cells. --- Circadian rhythms. --- Retina. --- Circadian rhythms --- Retina --- Biological Clocks --- Retinal Neurons --- Eye --- Periodicity --- Biological Science Disciplines --- Chronobiology Phenomena --- Sense Organs --- Natural Science Disciplines --- Neurons, Afferent --- Neurons --- Disciplines and Occupations --- Anatomy --- Physiological Phenomena --- Phenomena and Processes --- Cells --- Nervous System --- Retinal Ganglion Cells --- Physiology --- Circadian Clocks --- Circadian Rhythm --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Behavior, Circadian --- Biological clocks, Daily --- Circadian behavior --- Circadian clocks --- Circadian cycles --- Clocks, Circadian --- Cycles, Circadian --- Daily activity cycles --- Daily biological clocks --- Diel cycles --- Diurnal rhythms --- Rhythms, Circadian --- Medicine. --- Neurosciences. --- Ophthalmology. --- Neurobiology. --- Biomedicine. --- Posterior segment (Eye) --- Biological rhythms --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Neurosciences --- Diseases

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To create a forum for scientists and clinicians interested in degenerative retinal diseases, we began in 1984 to organize a biennial symposium on Retinal Degeneration as a satellite meeting of the International Congress of Eye Research. The timing and varying location of these meetings provides an important assembly for investigators from throughout the world to convene for presentation of their new findings on the causes and potential therapies for degenerative retinal disorders. The VIII International Symposium on Retinal Degeneration was held from July 28-25, 1998, at the Hotel Vier Jahreszeiten in Schluchsee, a small town in the Black Forest of southwestern Germany. Most of the participants in this meeting contributed to this volume, and we are appreciative of the efforts of each author in making this publication possible. The research presented at the meeting, and described in this proceedings volume, reflects a strong emphasis on the molecular genetic approach to understa- ing these disorders. Several of the papers provide important new insights into the mechanism of photoreceptor degeneration and cell death. A number of the studies are targeted at retarding or reversing the degeneration process. Included for the first time are presentations from all the principal laboratories involved in the field of visual prostheses-implant (chip) technology-in which investigations are targeted at restoring vision in eyes that have lost photoreceptor cells. A variety of diagnostic, clinical, histopathological, and physiological assessments of retinal degeneration in patients are also included.

Photoreceptors --- Retina --- Retinal Degeneration --- Retinal Degenetation --- Degeneration --- Treatment --- genetics --- physiopathology --- therapy --- Photoreceptors -- Congresses. --- Retinal degeneration -- Congresses. --- Retinal degeneration -- Treatment -- Congresses. --- Retinal Neurons --- Neurons, Afferent --- Photoreceptor Cells --- Retinal degeneration --- Medicine. --- Human genetics. --- Pharmacology. --- Human anatomy. --- Ophthalmology. --- Biomedical engineering. --- Medicine & Public Health. --- Human Genetics. --- Biomedical Engineering. --- Anatomy. --- Pharmacology/Toxicology. --- Toxicology. --- Biomedical Engineering and Bioengineering. --- Genetics --- Physiopathology --- Therapy --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Anatomy, Human --- Anatomy --- Human biology --- Human body --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Heredity, Human --- Physical anthropology --- Eye --- Physiological effect --- Diseases --- Dystrophy, Retinal --- Macular degeneration --- Retinal dystrophy --- Degeneration (Pathology)

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Flavor --- Food --- Saveur --- Aliments --- Periodicals --- Analysis --- Sensory evaluation --- Périodiques --- Analyse --- Analyse sensorielle --- Chemical senses --- Chemical senses. --- Flavor. --- Sensory evaluation. --- Chemoreceptor Cells --- Receptors, Sensory --- Analysis. --- Neural Receptors --- Sensory Neurons --- Sensory Receptors --- Nerve Endings, Sensory --- Neurons, Sensory --- Neuroreceptors --- Receptors, Neural --- Nerve Ending, Sensory --- Neural Receptor --- Neuron, Sensory --- Neuroreceptor --- Receptor Cell, Sensory --- Receptor Cells, Sensory --- Receptor, Neural --- Receptor, Sensory --- Sensory Nerve Ending --- Sensory Nerve Endings --- Sensory Neuron --- Sensory Receptor --- Sensory Receptor Cell --- Chemoreceptive Cells --- Cell, Chemoreceptive --- Cell, Chemoreceptor --- Cells, Chemoreceptive --- Cells, Chemoreceptor --- Chemoreceptive Cell --- Chemoreceptor Cell --- Assessment, Sensory --- Materials --- Sensory assessment --- Analysis of food --- Chemistry of food --- Food, Chemistry of --- Tastes --- Chemoreception --- Chemistry --- flavour --- flavour perception --- nutrition --- food chemistry --- Neurons, Afferent --- Sense Organs --- Chemotaxis --- Sensilla --- Evaluation --- Chemistry, Technical --- Sanitary chemistry --- Taste --- Senses and sensation --- Chemoreceptors --- Composition --- Sensory Receptor Cells. --- lectronic journals. --- Chemoreceptor Cells. --- Receptors, Sensory. --- Sensory Receptor Cells

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Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid.  Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis.  Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body.  Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases.  Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come.  It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.     .

Arteries -- Innervation -- Congresses. --- Carotid body -- Congresses. --- Chemoreceptors -- Congresses. --- Chemoreceptors --- Carotid body --- Arteries --- Circulatory and Respiratory Physiological Phenomena --- Sensory Receptor Cells --- Blood Vessels --- Inorganic Chemicals --- Publication Formats --- Paraganglia, Nonchromaffin --- Biological Science Disciplines --- Metabolic Phenomena --- Chalcogens --- Phenomena and Processes --- Elements --- Neurons, Afferent --- Cardiovascular System --- Natural Science Disciplines --- Peripheral Nervous System --- Chemicals and Drugs --- Publication Characteristics --- Disciplines and Occupations --- Neurons --- Nervous System --- Anatomy --- Cells --- Congresses --- Chemoreceptor Cells --- Oxygen --- Respiratory Physiological Phenomena --- Carotid Body --- Gases --- Metabolism --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Innervation --- Aortic paraganglia --- Aortic bodies --- Aortic glands --- Organs of Zuckerkandl --- Preaortal paraganglia --- Zuckerkandl-organs --- Zuckerkandl's bodies --- Carotid gland --- Carotid glomus --- Glomus caroticum --- Intercarotid body --- Nodulus caroticus --- Medicine. --- Human physiology. --- Neurosciences. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Neural sciences --- Neurological sciences --- Medical sciences --- Nervous system --- Human biology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Blood-vessels --- Chromaffin cells --- Nonchromaffin paraganglia --- Respiration --- Regulation --- Health Workforce --- Biomedicine, general.