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Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhancing thrombosis, impeding drug delivery, and disseminating tumor cells. These problems associated with tumor vasculature continue to attract great attention of scientists and clinicians interested in advancing the understanding of tumor biology and development of new drugs. This book complies a series of reviews that cover a broad spectrum of current topics related to the pathology of tumor blood vessels including mechanisms inducing new vessels, identification of new targets for inhibition of tumor angiogenesis, and potential clinical use of known and novel anti-angiogenic therapies. The book provides an update on tumor angiogenesis that could be useful for oncologists, cancer researchers and biologists with interests in vascular and endothelial cell behavior in the context of cancer.

Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Oncology

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This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions. .

Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Oncology. --- Tumors --- Growth. --- Cancer --- Neoplasm growth --- Tumor growth --- Growth --- Cancer research

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The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume.  The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Medicine. --- Cancer research. --- Immunology. --- Molecular biology. --- Oncology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Immunobiology --- Cancer research --- Clinical sciences --- Medical profession --- Tumors --- Cancer --- Neoplasm growth --- Tumor growth --- Tumor immunology --- Immunological aspects. --- Growth. --- Growth --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Pathology --- Physicians --- Oncology  . --- Health Workforce

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A wide range of ongoing research in the areas of controller design and information engineering reveals that the pace of technological change in this domain seems to be accelerating. The primary focus is on futuristic segments ranging from robotics, genomics to chemical feedstock and electrical storage. The main objective of this special issue was to provide a forum for researchers and practitioners to exchange their latest theoretical and technological achievements and to identify critical issues and challenges for future investigation on topics regarding advanced automation and control techniques based on information system technologies.

fractional calculus --- fractional-order control --- experimental tuning --- smart beam --- vibration suppression --- industrial internet of things --- prediction strategy --- proactive historian --- water industry --- lithium-ion batteries --- fast charging --- battery ageing --- sample and hold --- hierarchical clustering --- multidimensional scaling --- distances --- moving horizon estimation --- Kalman filter --- parameter estimation --- tumor growth estimation --- vibration --- control --- linear quadratic regulator (LQR) --- algebraic Riccati equation --- iteration --- state observer --- viscoelasticity --- mechatronic system --- 6DOF platform --- co-simulation platform --- robust control --- fractional order PID control --- linear parameter varying system --- n/a

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In this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.

Developmental biology. --- Tumors --- Growth. --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Cancer --- Neoplasm growth --- Tumor growth --- Oncology. --- Cytology. --- Medicine. --- Biochemistry. --- Developmental Biology. --- Cancer Research. --- Cell Biology. --- Molecular Medicine. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Cancer research. --- Cell biology. --- Molecular biology. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Cancer. --- Medicine --- Clinical biochemistry. --- Developmental Biology and Stem Cells. --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors