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Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of p
Fc receptors. --- Immune response. --- Anti-antibodies. --- Receptors, Fc --- Immunoglobulins --- Immunology --- Cell receptors --- Lymphocytes --- Macrophages --- Immunoglobulins. --- Antibody diversity.
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This volume is THE definitive, completely up-to-date, reference work for ALL researchers and clinicians working in autoimmunity. Up-to-Date: This is a timely critical review of more than 100 autoantibodies by leading experts in their respective fields, and includes many recent references. International Experts: The 120 Chapters have been written by the top international cadre of authors who have provided structured, expert contributions. Comprehensive: A total comprehensive perspective on the processes which induce, inhibit or otherwise affect autoantibodies in human
Immunology. Immunopathology --- Autoantibodies. --- Autoimmune Diseases --- etiology. --- Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Immunoglobulins --- Autoimmunity
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This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in
Immunoglobulins. --- Immune complexes. --- Antibody-antigen complexes --- Antigen-antibody complexes --- Antigens --- Immunoglobulins --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Bacterial immunoglobulin-binding proteins
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Lectins: Analytical Technologies covers both analytical and biological aspects of lectins (functional carbohydrate (complex sugar) recognition proteins) and provides researchers in the field with a resource containing background information and 'look-up' tables detailing lectin specificity and structures. Also included are methods and practical tips for designing new lectins from existing non-lectin proteins, automated approaches to lectin proteomics and high resolution mass spectrometry techniques. This book will be of interest to both novice and advanced researchers in biom
Lectins. --- Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Protectins --- Receptor-specific proteins --- Hemagglutinin --- Immunoglobulins
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The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking to unravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through theunderstanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and the exploitati
Immunoglobulins. --- Immunology --- Immunobiology --- Life sciences --- Serology --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- History.
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Monoclonal Antibodies now have applications in virtually all areas of biology and medicine, and much of the world's biotechnology industry has its foundations in the exploitation of this technology.The Third Edition of this well established book meets the needs of both newcomers to the area and experienced researchers, by providing an integrated treatment of both the production and application of monoclonal antibodies. As in previous editions, detailed and critical accounts of the theory, production, purification, fragmentation, storage and radiolabelling of monoclonal antibodies ar
Monoclonal antibodies --- Biotechnology. --- Diagnostic use. --- Monoclonal antibodies. --- Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning
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Quel est le lien entre immunologie et identité ? Au cœur de l’immunologie se trouvent les concepts de « soi » et de « non-soi », ainsi que ceux d’unicité et d’individualité. Les immunologistes contemporains affirment que, en se fondant sur le vocabulaire du soi et du non-soi, leur discipline apporte une réponse à la question de savoir ce qui fait l’identité d’un organisme à travers le temps. Cet ouvrage met en doute cette affirmation. S’appuyant sur des données récentes sur la tolérance immunitaire, le chimérisme ou encore la symbiose, il montre que la théorie du soi et du non-soi, qui domine l’immunologie depuis plus de cinquante ans, n’est plus adéquate. Il propose une autre théorie, la théorie de la continuité, dont l’un des objectifs est de rendre compte des nombreux cas dans lesquels un organisme tolère des entités étrangères, en particulier des bactéries. L’organisme doit alors être compris selon une perspective écologique : il est ouvert à l’extériorité, à l’autre, et en grande partie constitué par l’appropriation d’entités initialement « étrangères ». L’immunologie donne bien une définition de l’identité biologique, mais celle-ci est aux antipodes de la conception selon laquelle l’organisme serait une réalité fermée, définie de façon endogène et défendant son intégrité contre tout « non-soi ».
Spécificité (Immunologie) --- Immunologie. --- Immunité. --- Immunospecificity. --- Immunology. --- Immunity. --- Immunobiology --- Immunological specifics --- Serological specificity --- Specificity (Immunology) --- Life sciences --- Serology --- Antibody diversity --- Antigenic determinants --- Binding sites (Biochemistry) --- Immune recognition --- Immunology --- organisme --- immunité --- immunologie --- philosophie du vivant --- Biologie --- Immunologie --- Philosophie
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Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.
Immunoglobulins. --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Life Sciences --- Human Genetics --- Molecular Genetics --- Genetics and Molecular Biology --- Biochemistry
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A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems.
Immunoglobulins. --- Molecular neurobiology. --- Molecular neurology --- Nervous system --- Molecular biology --- Neurobiology --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Molecular aspects
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The articles in this volume have been selected to demonstrate the progress in the development of human antibody therapeutics for viral disease. Keck et al. review the nature of the immune response to the Hepatitis C virus (HCV) and the details of viral neutralization by antibodies, providing a conceptual model for the clinical use of HCV-specific antibodies. Huber et al. summarize the initial clinical experiences with antibody therapeutics for Human Immunodeficiency Virus that can be targeted to either the HIV virion or to host cell proteins. A discussion of the breadth immune strategies that is required to control human rabies is provided by Nagarajan et al., with a particular focus on India and other countries in which rabies is endemic. The development of pavilizumab for RSV prophylaxis is reviewed in Wu et al., in addition to results of antibody optimization studies that provide surprising insights and have broad general implications for anti-viral antibody engineering. Melhop and Diamond explicate the biology of West Nile Virus as a general model for flaviviruses, while using their cloned antibodies as a springboard to consider the mechanisms of WNV neutralization. The volume concludes with a description of methods to clone human antibodies in their native configurations, which access a class of antibodies that differ from those obtained by recombinant DNA or transgenic mouse methods. The articles in this volume are definitive and comprehensive reviews written by experts who have sought to define the principles of viral neutralization by human antibodies. They explore and anticipate the obstacles and opportunities that will be encountered as the power of human antibodies is harnessed to address the vast, un-met need for effective anti-viral therapeutics.
Immunoglobulins. --- Immunoglobulins --- Virus diseases --- Therapeutic use. --- Treatment. --- Chemotherapy. --- Antiviral agents --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Microbiology
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