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Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.

History of engineering & technology --- sol-gel --- electrospinning --- hydroxyapatite --- nanofiber --- antibacterial --- titanium --- antibacterial coatings --- nanocomposite coatings --- TiO2 photocatalytic --- orthopedic infections --- 3D printing --- nanofibers --- encapsulation --- protein diffusion --- in vivo tissue engineering --- immuno-isolation --- transplantation --- sputtering --- drug delivery --- wound dressing --- biocompatibility --- tissue engineering --- biomimetic scaffolds --- gelatin --- micromolding --- biomaterials --- poly(lactic acid) (PLLA) --- bioactive glass --- scaffolds --- composite fibres --- bone regeneration --- poly(vinylidene fluoride) --- composite nanofiber --- piezoelectricity --- antioxidant activity --- well-aligned nanofibers --- P(VDF-TrFE) --- piezoelectric nanogenerator --- preosteoblasts electrospinning --- silicone modified polyurethane nanofibers --- physical properties --- cell attachment --- cell proliferation --- cytotoxicity --- biopolymers --- packaging --- pharmaceutical --- biomedical --- alginate --- gelatin fibers --- ZnO particles --- antibacterial activity --- fabrication --- therapeutics --- biomedical applications --- antibody immobilization --- electrospun nanofibers --- TNF-α capture --- human articular chondrocytes --- rheumatoid arthritis --- microfluidic chip --- live assay --- hepatocellular carcinoma cells --- PLA95 --- guided tissue regeneration (GTR) --- electrospun fiber mats --- mechanobiology --- glioblastoma --- finite element modeling --- cancer treatment --- drug release --- nanomedicine --- biocompatible polymers --- hyperthermia

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Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.

hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing

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In this Special Issue, we present the state of the art in the field of pig genetics and genomics, including the identification of gene candidates linked to important pig traits and to nutritional modifications, with the aim of collecting the most recent advances. The published manuscripts focused on high-throughput methodologies, such as RNA sequencing, ATAC-seq, MACE-seq, chip-seq, and RRBS, and covered other fields of pig genetics. The pig (Sus scrofa) is the most common large mammal in the world. The Sus genus includes domestic pig and wild boar. Since the draft reference genome sequence of S. scrofa was assembled in 2012, the processes of identification of genes related to important phenotypic traits and of search of genetic markers for pig selection have been significantly refined. In addition, the newest wide-range high-throughput techniques, including microarrays, next-generation sequencing, and the recent PacBio sequencing platform providing ultra-long sequencing reads, allow identifying gene mutations and gene candidates throughout the whole genome, transcriptome, or epigenome and estimating quantitative traits important for breeding as well as the genetic backgrounds of inherited diseases.

Research & information: general --- Biology, life sciences --- Zoology & animal sciences --- HMOX1 gene --- promoter --- transcriptional regulation --- Hezuo Tibetan pig --- AQP3 --- pig --- intramuscular fat --- adipogenesis --- proliferation --- litter size --- total number born alive --- SNP (single nucleotide polymorphism) --- GWAS (Genome-Wide Association Studies) --- heat stress --- Duroc --- RNA-Seq --- NMR --- metabolome --- fatness --- obesity --- extracellular matrix --- fat deposition --- lipid metabolism --- NGS --- genetically modified pigs --- genome modifications --- transgenic pigs --- genetic engineering --- disease models --- recombinant proteins --- xenotransplantation --- xenoantigen --- coagulation system dysregulation --- CRISPR/Cas9 system --- non-homologous DNA ends joining (NHEJ) --- TIDE analysis --- off-target --- skeletal muscle fiber --- meat quality --- metabolic diseases --- lncRNA --- RNA-seq --- porcine β-defensin 2 --- CRISPR/Cas9 --- antimicrobial peptide --- disease-resistant animals --- porcine alveolar macrophages --- DNMT3B --- DNA methylation --- isoform --- TNF-α --- pigs --- fatty acids --- 3′quant mRNA-seq --- nutrigenomics --- TRIM26 --- antiviral response --- IFN-β --- poly (I:C) --- VSV --- PRRSV --- seminal plasma --- endometrium --- global gene expression --- microarray --- alternative splicing --- transcript --- protein --- domain --- single nucleotide polymorphism --- hypothalamus --- puberty --- circRNAs --- pubertal genes --- Duroc pigs --- growth traits --- weighted single-step GWAS --- SNP --- gene expression --- congenital defects --- transcriptomics --- swine --- Sus scrofa --- precision medicine --- lymphatic system --- whole-genome sequencing --- SNP array genotyping --- n/a --- 3'quant mRNA-seq

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Several lines of evidence indicate that healthy diet and exercise can prevent cardiovascular diseases, stroke, diabetes, and some types of cancer such as colon cancer, and smoking-related cancers. Dietary patterns defined as the quantities, proportions, variety, or combination of different foods and drinks, and the frequency with which they are habitually consumed are also associated with an increased or decreased incidence of chronic diseases. Lately, an association has been found between eating habits, exercise, and psychological and/or mental disorders. This Special Issue of Nutrients, entitled “Dietary Habits, Beneficial Exercise, and Chronic Diseases: Latest Advances and Prospects”, contains 20 manuscripts, either describing original research or reviewing the scientific literature, focused on the relationship between dietary habits (macronutrients, micronutrients, etc.) and/or exercise with metabolic, cardiovascular, neurological, mental, rheumatic, inflammatory, gastrointestinal, odontostomatological, and other chronic diseases.

muscle wasting --- cachexia --- sarcopenia --- probiotics --- prebiotics --- Lactobacillus --- intestinal permeability --- gut–brain axis --- health literacy --- education --- food --- students --- healthy lifestyle --- β-hydroxybutyrate (BHB) --- body mass index (BMI), type 1 diabetes --- type 2 diabetes (T2D) --- hemoglobin A1c (HbA1c) --- visceral adipose tissue (VAT) --- cardiovascular disease (CVD) --- high-density lipoprotein (HDL) --- low-density lipoprotein (LDL) --- Apolipoprotein B (ApoB) --- women’s health --- bone mineral density --- diet --- beach sports --- osteoporosis --- Mediterranean diet --- antioxidation --- metabolic health --- reproductive health --- gut microbiota --- non-communicable diseases --- flavonoids --- polyphenols --- resveratrol --- olive oil --- adult volunteers --- dietary intervention --- dietary patterns --- pilot study --- symbiotic agriculture --- metabolic dysfunction --- metabolic syndrome --- metabolome --- EHIS --- diabetes --- disease burden --- European Union --- policies --- dietary trajectories --- overweight --- obesity --- early childhood caries --- ECC --- dental caries --- health risk --- preschool children --- fish protein hydrolysate --- anxiety --- burying test --- rodent --- perceived stress --- psychological --- stress --- diet quality --- women --- reproductive age --- childbearing age --- a-priori --- a-posteriori --- sodium --- sodium intake --- inflammation --- systemic inflammation --- sodium induced inflammation --- CRP --- TNF-a --- IL-6 --- pediatric obesity --- children --- dietary interventions --- prevention --- pure fructose consumption --- adolescent --- blood pressure --- folic acid --- homocysteine --- inflammatory bowel disease --- microbiota --- crocin --- crocetin --- safranal --- effect direction plot --- complementary and alternative medicine --- medicinal plant --- CAM --- herbal medicine --- TNF-α --- qualitative synthesis --- dietary supplements --- food shopping quality indicators --- FSA-NPS DI --- dietary intake --- diet monitoring --- digital receipts --- dietary quality --- ischemic stroke --- Chinese Diet Balance Index 2016 --- DBI-16 --- Southeast China --- bone density --- bone resorption markers --- HDL-C --- LDL-C --- lipid profile --- cardiovascular disease --- exercise --- aerobic fitness --- multiple sclerosis --- nutrition --- physical activity --- body mass index --- dietary guideline --- reproductive age women --- n/a --- gut-brain axis --- women's health

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Advances in Nanomaterials in Biomedicine” provided a platform for more than 110 researchers from different countries to present their latest investigations in various fields of nanotechnology, new methods and nanomaterials intended for medical applications. Modern achievements in the field of nanoparticle-based diagnostics, drug delivery and the use of various nanomaterials in the treatment of diseases are presented in 11 original articles. The published reviews provide a comprehensive analysis of the current information on the use of nanomedicine in the treatment and diagnosis of cancer and liver fibrosis, in the field of solid tissue engineering and in drug delivery systems.

bone marrow-derived mesenchymal stromal cells --- rAAV vectors --- carbon dots --- SOX9 --- TGF-β --- cartilage repair --- silver nanoparticles --- Entada spiralis --- Ceiba pentandra --- antibacterial assay --- catalytic dye reduction --- osteoarthritis --- human articular cartilage --- polymeric micelles --- pro-inflammatory cytokines --- IL-1β --- TNF-α --- nanomaterials --- nanomedicine --- immunotherapy --- oncotherapy --- immune-checkpoint inhibitors --- immunogenic cell death --- nano-vaccines --- nano-conjugates --- immune response --- oxidative stress --- antioxidants --- nanoparticles --- biological nano-antioxidants --- gold nanoparticles --- radiation --- chemotherapy --- radiosensitizer --- drug delivery system --- chemoradiotherapy --- magnetoliposomes --- hydrogels --- magnetolipogels --- self-assembly --- fluorescence --- Förster resonance energy transfer --- polypropylenimine dendrimers --- polyethylenimines --- tyrosine-modified polypropylene-imines --- tyrosine-modified polyethlyenimines --- PPI-Y --- siRNA transfection --- polymeric nanoparticles --- carbosilane --- dendron --- triazine --- amphiphile --- vesicles --- pH-sensitive --- doxorubicin --- methotrexate --- leukaemia --- molecular ultrasound --- nanobubbles --- active targeting --- targeted microbubbles --- angiogenesis --- inflammation --- thrombosis --- clinical translation --- molecular imaging --- liver fibrosis --- diagnosis --- therapy --- theranostics --- targeted drug delivery --- lipid conjugates --- amphiphilic oligonucleotides --- phosphoryl guanidines --- nucleic acid delivery --- leukemia --- iron nanoparticles --- RNA-Seq --- cytotoxicity --- polymers --- biodegradable --- drug delivery --- pharmaceutical --- SQUID --- magnetic properties --- iron content --- magnetite nanoparticles --- superoxide --- aorta --- heart --- nano-biomaterials --- nanotechnology --- scaffolds --- hard tissue engineering --- AuNPs --- AuPEI-NPs --- AuBSA-NPs --- electron microscopy --- ultrastructure of HepG2 cells and spheroids --- ultrastructure of HEK293 cells and spheroids --- penetration of NPs into monolayer and spheroids --- gold nanostars --- photothermal therapy --- photoacoustic imaging --- computed tomography --- cancer --- theranostic agents --- biocompatible nanomaterials --- diagnostics --- nanocarriers --- tissue engineering