Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Proteases are enzymes that essentially ""eat"" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.

Microbial enzymes. --- Protease inhibitors. --- Proteolytic enzymes.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Virus inhibitors --- Virus diseases --- Antiviral agents --- Virus Inhibitors --- Virus Diseases --- Antiviral Agents --- immunology --- Antiviral Agents. --- Virus research --- Agents antiviraux --- Antiviraux --- Maladies à virus --- Virus --- Antiviral agents. --- Virus diseases. --- Virus inhibitors. --- immunology. --- Périodiques. --- Inhibiteurs --- Immunologie --- Antiviruses --- Viral diseases --- Viral infections --- Virus infections --- Antiviral drugs --- Antivirals --- Antiviral Drugs --- Agents, Antiviral --- Drugs, Antiviral --- Viruses --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Anti-infective agents --- Interferon Inducers --- Virus Inactivation --- Chemotherapy --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Virus Diseases. --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Antiviraux. --- Periodicals. --- Viral Protease Inhibitors. --- Inhibitor of Viral Protease --- Virus Protease Inhibitors --- Inhibitors, Viral Protease --- Inhibitors, Virus Protease --- Protease Inhibitor, Viral --- Protease Inhibitors, Viral --- Protease Inhibitors, Virus --- Viral Protease Inhibitor --- Viral Proteases --- antagonists & inhibitors --- Viral Inactivation --- Inactivation, Viral --- Inactivation, Virus

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest.  In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

Bones -- Cancer -- Treatment. --- Bones -- Cancer. --- Protease inhibitors --- Enzyme Inhibitors --- Proteins --- Medicine --- Pathologic Processes --- Receptors, Cell Surface --- Hydrolases --- Enzymes --- Amino Acids, Peptides, and Proteins --- Molecular Mechanisms of Pharmacological Action --- Pathological Conditions, Signs and Symptoms --- Health Occupations --- Membrane Proteins --- Enzymes and Coenzymes --- Pharmacologic Actions --- Disciplines and Occupations --- Chemicals and Drugs --- Diseases --- Chemical Actions and Uses --- Peptide Hydrolases --- Receptors, Proteinase-Activated --- Protease Inhibitors --- Pathology --- Carrier Proteins --- Inflammation --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Therapeutic use --- Proteolytic enzymes. --- Peptide hydrolases --- Proteases --- Medicine. --- Immunology. --- Infectious diseases. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Infectious Diseases. --- Cytology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.

Cancer -- Treatment. --- Protein drugs. --- Protein engineering. --- Recombinant proteins -- Therapeutic use. --- Amino Acids, Peptides, and Proteins --- Ubiquitins --- Diseases --- Enzyme Inhibitors --- Molecular Mechanisms of Pharmacological Action --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Neoplasms --- Protease Inhibitors --- Ubiquitin --- Proteins --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Cancer --- Treatment. --- Protein pharmaceuticals --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Human genetics. --- Immunology. --- Medical microbiology. --- Biochemistry. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- Human Genetics. --- Biochemistry, general. --- Drugs --- Oncology. --- Microbiology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Microbial biology --- Microorganisms --- Tumors --- Composition --- Cancer research

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.

Antineoplastic agents. --- Multiple myeloma -- Chemotherapy. --- Multiple myeloma -- Treatment. --- Multiple myeloma --- Antineoplastic agents --- Hemostatic Disorders --- Boron Compounds --- Heterocyclic Compounds, 1-Ring --- Paraproteinemias --- Acids, Noncarboxylic --- Lymphoproliferative Disorders --- Peptide Hydrolases --- Therapeutics --- Therapeutic Uses --- Neoplasms, Plasma Cell --- Enzyme Inhibitors --- Multienzyme Complexes --- Enzymes --- Hydrolases --- Blood Protein Disorders --- Organic Chemicals --- Heterocyclic Compounds --- Acids --- Immunoproliferative Disorders --- Pharmacologic Actions --- Hemorrhagic Disorders --- Multiprotein Complexes --- Vascular Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Inorganic Chemicals --- Molecular Mechanisms of Pharmacological Action --- Neoplasms by Histologic Type --- Boronic Acids --- Multiple Myeloma --- Antineoplastic Agents --- Drug Therapy --- Proteasome Endopeptidase Complex --- Protease Inhibitors --- Pyrazines --- Chemicals and Drugs --- Immune System Diseases --- Hematologic Diseases --- Macromolecular Substances --- Chemical Actions and Uses --- Cardiovascular Diseases --- Neoplasms --- Enzymes and Coenzymes --- Diseases --- Hemic and Lymphatic Diseases --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- Chemotherapy --- Treatment. --- Chemotherapy. --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Kahler's disease --- Plasma cell myeloma --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Apoptosis. --- Medicine & Public Health. --- Cancer Research. --- Pharmacology/Toxicology. --- Drugs --- Cancer --- B cells --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Oncology  . --- Toxicology. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Cell death --- Drug effects --- Medical pharmacology --- Medical sciences --- Pharmacy --- Cancer research --- Physiological effect