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PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP—poly ADP ribose polymerase—in cancer therapy. The volume covers the history of the discovery of PARP and its role in DNA repair. Additionally, it describes the discovery of the PARP family, and includes a discussion of other DNA maintenance-associated PARPs. As well, the volume features a section on the accessible chemistry behind the development of inhibitors. PARP inhibitors—PARPi—are a group of pharmacological inhibitors that are particularly good targets for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA-damaging agents used to treat cancer. Researchers have learned a great deal about the biology of PARP and how tumor-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy, and has led to heightened activity in this area.
Biomedicine. --- Cancer Research. --- Drug Resistance. --- Molecular Medicine. --- Medicine. --- Oncology. --- Drug interactions. --- Médecine --- Cancérologie --- Médicaments --- Interaction --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer research. --- Drug resistance. --- Molecular biology. --- Interactions, Drug --- Drugs --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Side effects --- Health Workforce --- NAD-ADP-ribosyltransferase --- Enzyme inhibitors --- Cancer --- Inhibitors --- Therapeutic use. --- Treatment. --- Cancer therapy --- Cancer treatment --- Antagonists, Enzyme --- Enzyme antagonists --- Enzymes --- Inhibitors, Enzyme --- Metabolic inhibitors --- Chemical inhibitors --- ADP-ribosyltransferase (Polymerizing) --- Poly(ADP-ribose) polymerase --- Poly(ADP-ribose) synthase --- Poly(ADP-ribose) synthetase --- Transferases --- Therapy --- Antagonists --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Resistance to drugs --- Pharmacology --- Cancer research
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Vibrio cholerae, the causative organism of the disease Cholera, colonizes the small intestine and produces several different toxins among which the enterotoxin, or more widely known as cholera toxin (CT), happens to be the major virulence determinant that is responsible for the diarrheal syndrome. This book provides for the first time comprehensive and up-to-date information about all the toxins of Vibrio cholerae, their physical and chemical structures, their biosynthesis and its genetic regulation, their physiology, the molecular biology of their interactions with the host as well as their role in the development of an appropriate and effective cholera vaccine. It also offers relevant and necessary background information on the basic biology of the Vibrio cholerae cell and cholera bacteriophages.
Cholera toxin. --- Cholera toxin --- Bacterial Toxins --- ADP Ribose Transferases --- Enterotoxins --- Toxins, Biological --- Pentosyltransferases --- Biological Factors --- Glycosyltransferases --- Chemicals and Drugs --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Cholera Toxin --- Biology --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Infectious Diseases --- Enterotoxins. --- Enterotoxin --- Cholera enterotoxin --- Cholera exotoxin --- Choleragen --- Choleragenoid --- CT (Cholera toxin) --- CTX (Cholera toxin) --- Procholeragenoid --- Vibrio cholerae enterotoxin --- Medicine. --- Medical microbiology. --- Pharmacology. --- Food --- Biochemistry. --- Cell biology. --- Microbiology. --- Biomedicine. --- Medical Microbiology. --- Food Science. --- Biochemistry, general. --- Cell Biology. --- Pharmacology/Toxicology. --- Biotechnology. --- Bacterial toxins --- NAD-ADP-ribosyltransferase --- Food science. --- Cytology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Science --- Microbial biology --- Microorganisms --- Toxicology --- Composition --- Food—Biotechnology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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