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Book
The CliniBook : clinical gene transfer : state-of-the-art.
Author:
ISBN: 1299276822 2842542371 9782842542375 9782842542375 2842541715 9782842541712 9782842541712 9781299276826 Year: 2012 Publisher: Paris EDP sciences

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Abstract

This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation.


Periodical
Molecular therapy.
Authors: ---
ISSN: 15250024 Year: 2000 Publisher: San Diego, CA : Amsterdam : New York : Academic Press, Elsevier Nature Pub. Group

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Keywords

Gene therapy --- Molecular genetics --- Thérapie génique --- Gene therapy. --- Molecular genetics. --- Genetic Therapy. --- Molecular Biology. --- Gene Transfer Techniques. --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Gene --- Therapy, Somatic Gene --- Gene Therapy --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Genetic Therapy --- Gene Therapy Techniques --- Molecular Biology --- Genetic engineering --- Therapeutics --- Transgenes --- Genetic Phenomena --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Genetics --- Molecular biology --- Thérapie génique


Periodical
The journal of gene medicine.
Authors: ---
ISSN: 15212254 1099498X Year: 1999 Publisher: New York, NY : Chichester, West Sussex, UK : John Wiley & Sons, John Wiley & Sons, Ltd.

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Keywords

Genetic transformation --- Gene therapy --- Cellular therapy --- Gene Transfer Techniques. --- Genetic Therapy. --- Thérapie génique --- Thérapie cellulaire --- Cellular therapy. --- Gene therapy. --- Genetic transformation. --- Gene Transfer --- Gene Therapy --- Therapy, Gene --- Gene transfer --- Transformation (Genetics) --- DNA Therapy --- Gene Therapy, Somatic --- Genetic Therapy, Gametic --- Genetic Therapy, Somatic --- Therapy, DNA --- Therapy, Somatic Gene --- Somatic Gene Therapy --- Gametic Genetic Therapies --- Gametic Genetic Therapy --- Genetic Therapies --- Genetic Therapies, Gametic --- Genetic Therapies, Somatic --- Somatic Genetic Therapies --- Somatic Genetic Therapy --- Therapies, Gametic Genetic --- Therapies, Genetic --- Therapies, Somatic Genetic --- Therapy, Gametic Genetic --- Therapy, Genetic --- Therapy, Somatic Genetic --- Cell therapy --- Cells --- Therapy, Cellular --- Therapeutic use --- Genetic engineering --- Therapeutics --- Genetic recombination --- Microbial genetics --- Nucleic acids --- Transfection --- Gene Transfer Techniques --- Genetic Services --- Genes, Transgenic, Suicide --- Organotherapy --- Therapeutics, Physiological --- Transplantation of organs, tissues, etc. --- Cell transplantation --- Gene Transfer. --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Genetic Therapy --- Transgenes --- Genetics --- Gene Therapy. --- Gene Therap. --- Gene Transfer, Horizontal --- Genetic Structures --- Genetic Phenomena --- Recombination, Interspecific --- Gene Transfer, Lateral --- Horizontal Gene Transfer --- Lateral Gene Transfer --- Recombination, Interspecies --- Gene Transfers, Lateral --- Interspecies Recombination --- Interspecific Recombination --- Lateral Gene Transfers --- Thérapie génique. --- Transformation, Genetic. --- Genetic Transformation --- Genetic Transformations --- Transformations, Genetic --- Crosses, Genetic --- Transduction, Genetic --- Immunotherapy, Adoptive --- Adoptive Immunotherapy --- CAR T-Cell Therapy --- Cellular Immunotherapy, Adoptive --- Chimeric Antigen Receptor Therapy --- Immunotherapy, Adoptive Cellular --- Adoptive Cellular Immunotherapy --- Adoptive Cellular Immunotherapies --- Adoptive Immunotherapies --- CAR T Cell Therapy --- CAR T-Cell Therapies --- Cellular Immunotherapies, Adoptive --- Immunotherapies, Adoptive --- Immunotherapies, Adoptive Cellular --- T-Cell Therapies, CAR --- T-Cell Therapy, CAR --- Therapies, CAR T-Cell --- Therapy, CAR T-Cell --- Receptors, Chimeric Antigen --- Killer Cells, Lymphokine-Activated --- Cytapheresis --- Lymphocytes, Tumor-Infiltrating --- Monocytes, Activated Killer


Book
Alginate biomaterial : drug delivery strategies and biomedical engineering
Authors: ---
ISBN: 981196937X 9811969361 Year: 2023 Publisher: Singapore : Springer Nature Singapore : Imprint: Springer,

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This book focuses on recent trends of research on alginate-based biomaterials in Drug Delivery strategies and biomedical engineering. It contains the widely used alginate-based biomaterials as micro to nano-controlled drug delivery (oral, ocular delivery, topical delivery, etc.) and its fabrication technology, characterization, and biomedical aspects (such as cancer therapy, tissue engineering, gene delivery, vaccine delivery, enzyme immobilization, wound healing, dental applications, etc.) in a single book. The chapters cover updated information, current research trends, informatics, and all aspects of applications. Alginate is a U.S. Food and Drug Administration (FDA)-approved natural biomaterial and has diverse biomedical applications. In recent years, researchers and scientists are working on the alginate-based drug delivery systems that have been designed and characterized as a matrix, micro to nanocarriers, fibers, composite/scaffolds, etc. Alginate has versatile properties such as biodegradable, biocompatible, nontoxic, and easily available. This book especially highlights both the drug delivery strategies and biomedical engineering aspects such as controlled drug delivery, drug targeting to the site of action, cancer therapy, gene and vaccine delivery, enzyme immobilization, tissue engineering, and regenerative medicine. .

Keywords

Drug delivery systems. --- Biomaterials. --- Therapeutics. --- Biology—Technique. --- Genetic engineering. --- Cancer—Treatment. --- Biomedical engineering. --- Alginates. --- Drug Delivery Systems --- Nanoparticle Drug Delivery System. --- Biomedical Engineering. --- Neoplasm --- Gene Transfer Techniques. --- Tissue Scaffolds. --- Drug Delivery. --- Gene Delivery. --- Cancer Therapy. --- Biomedical Engineering and Bioengineering. --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Medical treatment --- Therapy --- Treatment of diseases --- Treatments for diseases --- Clinical medicine --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Tissue Scaffolding --- Scaffold, Tissue --- Scaffolding, Tissue --- Scaffoldings, Tissue --- Scaffolds, Tissue --- Tissue Scaffold --- Tissue Scaffoldings --- Gene Delivery Systems --- Gene Transfer Technique --- Transgenesis --- Delivery System, Gene --- Delivery Systems, Gene --- Gene Delivery System --- Technique, Gene Transfer --- Techniques, Gene Transfer --- Transfer Technique, Gene --- Transfer Techniques, Gene --- Genetic Therapy --- Transgenes --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Biomedical Technology --- NDDSs --- Nano Delivery System --- Nano Drug Delivery Systems --- Nano-Drug Delivery System --- Nanoparticle Based Drug Delivery System --- Delivery System, Nano --- Delivery System, Nano-Drug --- Delivery Systems, Nano --- Delivery Systems, Nano-Drug --- Nano Delivery Systems --- Nano Drug Delivery System --- System, Nano Delivery --- System, Nano-Drug Delivery --- Systems, Nano Delivery --- Systems, Nano-Drug Delivery --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Dosage Forms --- Alginate --- Alginic Acid, Barium Salt --- Alginic Acid, Calcium Salt --- Alginic Acid, Copper Salt --- Alginic Acid, Potassium Salt --- Alginic Acid, Sodium Salt --- Alloid G --- Barium Alginate --- Calcium Alginate --- Calginat --- Copper Alginate --- Kalrostat --- Kalrostat 2 --- Kaltostat --- Potassium Alginate --- Sodium Alginate --- Sodium Calcium Alginate --- Vocoloid --- Xantalgin --- poly(Mannuronic Acid), Sodium Salt --- Alginate, Barium --- Alginate, Calcium --- Alginate, Copper --- Alginate, Potassium --- Alginate, Sodium --- Alginate, Sodium Calcium --- Calcium Alginate, Sodium --- therapy. --- Delivery systems

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