Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Collagen. --- Collogen --- Extracellular matrix proteins --- Connective tissues

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.Key Features* Provides state-of-the-art information on a field with broad implications to many areas of biology* Includes detailed coverage of the stru

Metalloproteinases. --- Extracellular matrix proteins. --- Matrix proteins --- Metalloproteases --- Proteins --- Metalloenzymes --- Proteinase --- Extracellular matrix proteins --- Metalloproteinases

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Fibronectins. --- Cold-insoluble globulins --- Fibronectin --- Blood proteins --- Extracellular matrix proteins --- Globulins --- Glycoproteins --- Lectins

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This e-book also explains processes under the control of some enzymes - TNAP and metalloproteases (MMPs) - such as intracellular regulation in bone and dentine, splicing, respective roles of cleavage products, SIBLINGs, nucleation and crystal growth and regulation.

Extracellular matrix proteins. --- Dentin. --- Bone --- Bones --- Calcification --- Connective tissues --- Skeleton --- Dentine --- Dental pulp --- Teeth --- Matrix proteins --- Proteins --- Physiology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.

Cancer -- Pathophysiology. --- Extracellular matrix proteins. --- Neoplasms -- Physiopathology. --- Cancer --- Extracellular matrix proteins --- Scleroproteins --- Diseases --- Cell Physiological Processes --- Cell Communication --- Neoplasms --- Extracellular Matrix Proteins --- Proteins --- Cell Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Medicine --- Oncology --- Health & Biological Sciences --- Pathophysiology --- Pathophysiology. --- Matrix proteins --- Medicine. --- Cancer research. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pharmacology/Toxicology. --- Oncology. --- Cytology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect