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This book presents the clinical features, invasive and non-invasive modalities of diagnosis of conjunctival and corneal infections, especially atypical clinical situations in unusual cases of keratitis, and manage the disease entity. Infections of cornea continues to be the leading cause of ocular morbidity and blindness worldwide. Early diagnosis helps in better outcome. Proper understanding of the microbiological and clinical characteristics of this disease entity enables ophthalmologists to initiate appropriate therapy. Corneal infections, especially due to uncommon organisms, are difficult to diagnose and treat. With 17 chapters, this volume covers the entire spectrum of corneal and conjunctival infections. This is a quick go-to book for general as well as specialist ophthalmologists.

Ophthalmology. --- Medicine --- Eye --- Diseases --- Conjunctiva --- Cornea --- Diseases. --- Infections. --- Keratomalacia --- Ophthalmia

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Herpes Simplex Virus Epithelial Keratitis provides a kind of ‘living histology’, revealing both morphological and dynamic features of the disease, and explaining the mechanisms behind them. It discusses in detail: ° the result of herpes simplex virus impact on the living human epithelium ° the step-by-step dynamics of healing during a successful treatment ° the complications and sequelae of infection The case studies presented demonstrate the application of these observations in clinical practice. This unique guide offers insights helpful in differential diagnostics and the recognition of lesser known variants, as well as complications. It is also useful for the follow–up of treatment results and the differentiation between an active infection and sequelae. It is an invaluable aid for ophthalmologists and researchers working with ocular surfaces.

Cervix uteri -- Etiology. --- Conjunctiva -- Diseases. --- Herpes simples virus. --- Herpes simplex. --- Keratitis. --- Keratitis --- Herpesvirus diseases --- Conjunctiva --- Cornea --- Keratitis, Herpetic --- Conjunctival Diseases --- Herpesvirus 1, Human --- Atlases --- Pathology --- Eye Diseases --- Simplexvirus --- Eye Infections, Viral --- Herpes Simplex --- Anterior Eye Segment --- Publication Formats --- Medicine --- Eye --- Publication Characteristics --- Corneal Diseases --- Health Occupations --- Herpesviridae Infections --- Alphaherpesvirinae --- Eye Infections --- Diseases --- Virus Diseases --- DNA Virus Infections --- Sense Organs --- Disciplines and Occupations --- Herpesviridae --- DNA Viruses --- Anatomy --- Vertebrate Viruses --- Viruses --- Organisms --- Ophthalmology & Optometry --- Health & Biological Sciences --- Inflammation --- Medicine. --- Infectious diseases. --- Ophthalmology. --- Medicine & Public Health. --- Infectious Diseases. --- Skin --- Infections --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases

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Biomedical image processing is an interdisciplinary field involving a variety of disciplines, e.g., electronics, computer science, physics, mathematics, physiology, and medicine. Several imaging techniques have been developed, providing many approaches to the study of the human body. Biomedical image processing is finding an increasing number of important applications in, for example, the study of the internal structure or function of an organ and the diagnosis or treatment of a disease. If associated with classification methods, it can support the development of computer-aided diagnosis (CAD) systems, which could help medical doctors in refining their clinical picture.

MR brain segmentation --- fuzzy clustering --- object extraction --- silhouette analysis --- DICOM processing --- 3D modeling --- semantic segmentation --- convolutional neural networks --- kidney biopsy --- kidney transplantation --- glomerulus detection --- glomerulosclerosis --- pattern recognition --- hemoglobin --- anemia --- human tissues --- conjunctiva --- non-invasive medical device --- training size --- deep learning --- convolutional neural network --- U-Net --- segmentation --- artificial intelligence --- digital pathology --- kidney fibrosis --- blood vessel segmentation --- inferior vena cava --- ultrasound imaging --- binary tree model --- pulsatility --- fluid volume assessment --- n/a

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The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.

MPC polymer --- dry eye --- ocular surface --- lacrimal fluid --- mucin --- 3D bioprinting --- cornea --- retina --- ophthalmology --- tissue regeneration --- electrospinning --- conjunctiva --- decellularized tissue matrix --- small intestinal submucosa --- urinary bladder matrix --- polycaprolactone --- fiber --- tissue engineering --- stratification --- conjunctival epithelial cells --- hydrogel --- keratoplasty --- scaffold --- collagen --- advanced therapy medicinal product --- ATMP --- cell therapy --- gene therapy --- eye --- ocular --- regulatory --- marketing authorization --- double-crosslinking --- carbodiimide --- glutaraldehyde --- sodium metabisulfite --- sodium borohydride --- EDC/NHS --- stem cells --- retinal diseases --- optic nerve diseases --- cell replacement --- cell sources --- advanced therapies --- ocular mucosa --- blindness --- CLET --- limbal niche --- limbal stem cell --- LSCD --- mesenchymal stem cell transplantation --- MSCT --- corneal limbus --- decellularized xenograft --- recellularization --- mesenchymal stem cells --- n/a