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The theory of a stem-cell origin of cancer is neither ground breaking nor earth shattering. Many prominent investigators have established the foundation for this concept and performed the vital experiments to support its validity and merit. The purpose of this book is to illustrate how this theory may completely transform our current views and perspectives about cancer. It is anticipated that the variety of ramifications of a stem-cell origin of cancers will be embraced by the medical research community to bring new treatment modalities to the cancer patient. "The stem-cell theory of cancer has significant biologic and clinical consequences. Though components remain open to debate the fundamental observations are grounded in scientific experimentation. This text explains the conceptual aspects of cancer stem cells with an emphasis on the implications for our patients." - Steven T. Rosen, M.D. Series Editor .

Cancer -- Epidemiology. --- Cancer -- Etiology. --- Cancer -- Prevention. --- Cancer --- Stem cells --- Neoplasms --- Diseases --- Oncology --- Medicine --- Health & Biological Sciences --- Etiology --- Stem cells. --- Etiology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Medicine. --- Cancer research. --- Human genetics. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Human Genetics. --- Cells

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Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Biomedicine. --- Cancer Research. --- Laboratory Medicine. --- Oncology. --- Medicine. --- Medical laboratories. --- Médecine --- Cancérologie --- Cancer -- Chemotherapy. --- Cancer -- Etiology. --- Cancer -- Genetic aspects. --- Cancer -- Molecular aspects. --- Molecular biology. --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Chemotherapy. --- Molecular aspects. --- Etiology. --- Genetic aspects. --- Cancer genetics --- Molecular biochemistry --- Molecular biophysics --- Cancer research. --- Laboratory medicine. --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer genes --- Antineoplastic agents --- Treatment --- Oncology  . --- Tumors --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Cancer research

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Breast Cancer is the most common tumor in women and it is the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland had greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.

Breast -- Cancer -- Diagnosis. --- Breast -- Cancer -- Etiology. --- Breast -- Cancer -- Genetic aspects. --- Breast -- Cancer -- Treatment. --- Breast --- Breast Diseases --- Neoplasms by Site --- Neoplasms --- Skin Diseases --- Skin and Connective Tissue Diseases --- Diseases --- Breast Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Etiology --- Diagnosis --- Treatment --- Genetic aspects --- Diagnosis. --- Etiology. --- Genetic aspects. --- Treatment. --- Medicine. --- Oncology. --- Pathology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Oncology  . --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Excision

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Over the years of cancer investigation a lot of discoveries in this field were made, and many associations between various biological carcinogens and cancer were revealed. Some of them are credibly determined, thus these infectious agents (human papilloma virus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, human herpes virus 8, human T-cell lymphotropic virus 1, human immunodeficiency virus, Merkel cell polyomavirus, Helicobacter pylori, Opisthorchis viverrini, Clonorchis sinensis, Schistosoma haematobium) are recognized as carcinogens and probable carcinogens by International Agency for Research on Cancer (IARC). The problem is of large importance, since share of infectious agents-related cancer cases is steadily increasing, reaching 25% according to certain estimates. It is worth noting that many of cancer cases are caused by infectious agents other than «conventional ones» like HPV, EBV, HBV, HCV, H.pylori etc. In recent years, a number of significant breakthroughs in the field were performed, such as the discovery of the microbiota role in cancer causation. Here in this book, almost all connections between «unconventional» carcinogenic infectious agents and cancer are described and analyzed comprehensively. The monograph was written with the idea that the language and concept will be rather simple and understandable for the wide audience, but the information contained in the book will be useful even for researchers working in the field of biological carcinogenesis who are familiar with the problem. Infectious Agents and Cancer may also be helpful for PhD, graduate and undergraduate students of biomedical faculties, and for their lecturers as well. The main idea of this book is to attract the attention to the problem of infectious agents causing human cancer other than the known biological carcinogens.  .

Cancer -- Etiology. --- Cancer -- Immunological aspects. --- Chronic diseases -- Etiology. --- Medicine. --- Cancer --- Diseases --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Etiology --- Tumors. --- Virus diseases. --- Bacterial diseases. --- Infection. --- Etiology. --- Infectious diseases --- Bacterial infections --- Viral diseases --- Viral infections --- Virus infections --- Tumours --- Cancer research. --- Microbiology. --- Bacteriology. --- Biomedicine. --- Cancer Research. --- Biomedicine general. --- Medical microbiology --- Communicable diseases --- Medical bacteriology --- Pathogenic bacteria --- Medical virology --- Pathogenic viruses --- Pathology --- Cysts (Pathology) --- Causes and theories of causation --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Microbiology --- Microbial biology --- Biology --- Microorganisms --- Tumors --- Health Workforce --- Biomedicine, general. --- Cancer research

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The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.

Cancer -- Etiology. --- Rho GTPases --- Cancer --- Monomeric GTP-Binding Proteins --- Diseases --- rho GTP-Binding Proteins --- Neoplasms --- GTP-Binding Proteins --- Intracellular Signaling Peptides and Proteins --- GTP Phosphohydrolases --- Peptides --- Proteins --- Carrier Proteins --- Amino Acids, Peptides, and Proteins --- Acid Anhydride Hydrolases --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Medicine --- Human Anatomy & Physiology --- Oncology --- Animal Biochemistry --- Health & Biological Sciences --- Etiology --- Rho GTPases. --- G proteins. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Rho G proteins --- Rho GTP-binding proteins --- Medicine. --- Cancer research. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pharmacology/Toxicology. --- Membrane proteins --- G proteins --- Guanosine triphosphatase --- Oncology. --- Cytology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect