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Measles is a disease of public health importance that is associated with high morbidity and mortality particularly in developing countries. In recent years widespread application of measles vaccine among children has led to decline in morbidity and mortality attributed to measles. In the city of Gweru in Zimbabwe operations research was carried on the epidemiology and control of measles. On account of these studies, a seven year multiple dose measles vaccination intervention was carried out in Gweru in 1990-1996. The results of this intervention played a significant role in the debate that led to the adoption of the WHO/UNICEF current policy on use of multiple dose measles vaccination strategies in the control of measles in developing countries. A critical lesson that has arisen from the Gweru city measles operations research effort has been that fairly low cost, simple research makes a world of difference in providing insight into the epidemiology and control of locally endemic disease conditions.--
Measles --- Morbilli --- Rubeola --- Virus diseases --- Vaccination --- Zimbabwe
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Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.
Measles -- Vaccination. --- Measles virus. --- Measles. --- Medical virology. --- Medicine. --- Morbilli virus (Measles virus) --- Virology. --- Biomedicine. --- Microbiology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Morbilliviruses --- Medical microbiology --- Virology --- Virus diseases
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Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.
Measles -- Pathogenesis. --- Measles -- Vaccination. --- Measles virus. --- Measles --- Measles Vaccine --- Measles virus --- Viral Vaccines --- Morbillivirus --- Morbillivirus Infections --- Vaccines --- Paramyxovirinae --- Paramyxoviridae Infections --- Paramyxoviridae --- Mononegavirales Infections --- Biological Products --- Complex Mixtures --- RNA Virus Infections --- Mononegavirales --- Virus Diseases --- RNA Viruses --- Chemicals and Drugs --- Diseases --- Viruses --- Vertebrate Viruses --- Organisms --- Microbiology & Immunology --- Infectious Diseases --- Medicine --- Biology --- Health & Biological Sciences --- Pathogenesis. --- Vaccination. --- Morbilli --- Rubeola --- Morbilli virus (Measles virus) --- Preventive inoculation --- Medicine. --- Vaccines. --- Virology. --- Infectious diseases. --- Biomedicine. --- Infectious Diseases. --- Vaccine. --- Microbiology --- Biologicals --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Virus diseases --- Morbilliviruses --- Medical virology. --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medical microbiology --- Virology
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Immunology. Immunopathology --- MEDICAL --- Infectious Diseases --- Viral Vaccines --- Bacterial Vaccines --- Vaccines --- Biological Products --- Complex Mixtures --- Chemicals and Drugs --- Pertussis Vaccine --- Rubella Vaccine --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Pertussis vaccines --- Rubella vaccines --- Whooping cough --- Rubella --- Side effects --- Vaccination --- Complications --- Fourth disease --- German measles --- Measles, German --- Rosella --- Röteln --- Rubeola notha --- Three-day measles --- Pertussis --- Bordetella pertussis vaccines --- Pertussis vaccine --- Whooping cough vaccines --- Togavirus infections --- Cough --- Gram-negative bacterial infections --- Respiratory infections --- Viral vaccines --- Bacterial vaccines
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Dangerous Pregnancies tells the largely forgotten story of the German measles epidemic of the early 1960's and how it created national anxiety about dying, disabled, and "dangerous" babies. This epidemic would ultimately transform abortion politics, produce new science, and help build two of the most enduring social movements of the late twentieth century--the reproductive rights and the disability rights movements. At most a minor rash and fever for women, German measles (also known as rubella), if contracted during pregnancy, could result in miscarriages, infant deaths, and serious birth defects in the newborn. Award-winning writer Leslie J. Reagan chronicles for the first time the discoveries and dilemmas of this disease in a book full of intimate stories--including riveting courtroom testimony, secret investigations of women and doctors for abortion, and startling media portraits of children with disabilities. In exploring a disease that changed America, Dangerous Pregnancies powerfully illuminates social movements that still shape individual lives, pregnancy, medicine, law, and politics.
Abnormalities, Human --- Abortion --- Disability awareness --- Rubella in pregnancy --- Rubella --- Fourth disease --- German measles --- Measles, German --- Rosella --- Röteln --- Rubeola notha --- Three-day measles --- Togavirus infections --- Virus diseases in pregnancy --- Awareness --- Abortion, Induced --- Feticide --- Foeticide --- Induced abortion --- Pregnancy termination --- Termination of pregnancy --- Birth control --- Fetal death --- Obstetrics --- Reproductive rights --- Abnormalities --- Anomalies, Congenital --- Birth defects --- Congenital abnormalities --- Congenital anomalies --- Defects, Birth --- Deformities --- Developmental abnormalities --- Human abnormalities --- Malformations, Congenital --- Morphology --- Pathology --- Teratogenesis --- Teratology --- History. --- Surgery --- History --- Rubella - United States - History --- Rubella in pregnancy - United States - History --- Abortion - United States - History --- Abnormalities, Human - United States - History --- Disability awareness - United States - History --- 20th century american culture. --- 20th century american medical history. --- abortion politics. --- abortion. --- children with disabilities. --- courtroom testimony. --- dangerous babies. --- disability rights movement. --- disability. --- disabled babies. --- disease. --- doctor. --- dying babies. --- family. --- german measles epidemic. --- german measles. --- health. --- infant deaths. --- medicine. --- miscarriages. --- motherhood. --- mothers. --- national anxiety. --- newborn babies. --- parenthood. --- pregnancy. --- pregnant women. --- reproductive rights movement. --- rubella. --- science. --- serious birth defects. --- social movements.
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Immunization. --- Vaccination --- Immunization --- Autism --- Measles-Mumps-Rubella Vaccine --- Safety --- Autistic Disorder --- Mumps Vaccine --- Immunologic Techniques --- Vaccines, Combined --- Measles Vaccine --- Communicable Disease Control --- Primary Prevention --- Rubella Vaccine --- Accident Prevention --- Child Development Disorders, Pervasive --- Immunotherapy --- Viral Vaccines --- Public Health Practice --- Vaccines --- Accidents --- Preventive Health Services --- Investigative Techniques --- Mental Disorders Diagnosed in Childhood --- Immunomodulation --- Public Health --- Biological Products --- Biological Therapy --- Health Services --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Mental Disorders --- Complex Mixtures --- Health Care Facilities, Manpower, and Services --- Environment and Public Health --- Therapeutics --- Psychiatry and Psychology --- Health Care --- Chemicals and Drugs --- Public Health - General --- Health & Biological Sciences --- Complications --- Autism. --- Complications. --- Autistic disorder --- Complications and sequelae --- Side effects --- Autism spectrum disorders --- Hyperlexia
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A creature of Jewish mythology, a golem is an animated being made by man from clay and water who knows neither his own strength nor the extent of his ignorance. Like science and technology, the subjects of Harry Collins and Trevor Pinch's previous volumes, medicine is also a golem, and this Dr. Golem should not be blamed for its mistakes-they are, after all, our mistakes. The problem lies in its well-meaning clumsiness. Dr. Golem explores some of the mysteries and complexities of medicine while untangling the inherent conundrums of scientific research and highlighting its vagaries. Driven by the question of what to do in the face of the fallibility of medicine, Dr. Golem encourages a more inquisitive attitude toward the explanations and accounts offered by medical science. In eight chapters devoted to case studies of modern medicine, Collins and Pinch consider the prevalence of tonsillectomies, the placebo effect and randomized control trials, bogus doctors, CPR, the efficacy of Vitamin C in fighting cancer, chronic fatigue syndrome, AIDS cures, and vaccination. They also examine the tension between the conflicting faces of medicine: medicine as science versus medicine as a source of succor; the interests of an individual versus the interests of a group; and the benefits in the short term versus success rates in the long term. Throughout, Collins and Pinch remind readers that medical science is an economic as well as a social consideration, encapsulated for the authors in the timeless struggle to balance the good health of the many-with vaccinations, for instance-with the good health of a few-those who have adverse reactions to the vaccine. In an age when the deaths of research subjects, the early termination of clinical trials, and the research guidelines for stem cells are front-page news, Dr. Golem is a timely analysis of the limitations of medicine that never loses sight of its strengths.
Medicine, Popular. --- Medicine --- Health Workforce --- Philosophy. --- medicine, medical, sociology, science, scientific research, technology, tonsillectomies, placebo effect, randomized control trials, bogus doctors, cpr, vitamin c, cancer, chronic fatigue syndrome, aids, cures, treatment, vaccination, economics, social, vaccinations, vaccines, health, healthy, philosophy, healthcare, fibromyalgia, diseases, mumps, measles, rubella, cardiopulmonary resuscitation, diagnosis, uncertainty.
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Black women have higher rates of premature birth than other women in America. This cannot be simply explained by economic factors, with poorer women lacking resources or access to care. Even professional, middle-class black women are at a much higher risk of premature birth than low-income white women in the United States. Dána-Ain Davis looks into this phenomenon, placing racial differences in birth outcomes into a historical context, revealing that ideas about reproduction and race today have been influenced by the legacy of ideas which developed during the era of slavery. While poor and low-income black women are often the "mascots" of premature birth outcomes, this book focuses on professional black women, who are just as likely to give birth prematurely. Drawing on an impressive array of interviews with nearly fifty mothers, fathers, neonatologists, nurses, midwives, and reproductive justice advocates, Dána-Ain Davis argues that events leading up to an infant's arrival in a neonatal intensive care unit (NICU), and the parents' experiences while they are in the NICU, reveal subtle but pernicious forms of racism that confound the perceived class dynamics that are frequently understood to be a central factor of premature birth. The book argues not only that medical racism persists and must be considered when examining adverse outcomes--as well as upsetting experiences for parents--but also that NICUs and life-saving technologies should not be the only strategies for improving the outcomes for black pregnant women and their babies. Davis makes the case for other avenues, such as community-based birthing projects, doulas, and midwives, that support women during pregnancy and labor are just as important and effective in avoiding premature births and mortality. -- Provided by publisher. A troubling study of the role that medical racism plays in the lives of black women who have given birth to premature and low birth weight infants. -- Provided by publisher. "'Reproductive Injustice: Racism, Pregnancy, and Premature Birth' explores the issues of racism, medicine, and motherhood"--
Race discrimination --- African American women --- Discrimination in medical care --- Reproductive health services --- Reproductive Health Services --- African Americans --- Racism --- Health aspects --- Medical care --- Social aspects --- United States. --- Baby Doe rules. --- Black feminist framework. --- Children’s Bureau. --- German measles. --- March of Dimes. --- NICU. --- NICUs. --- Sheppard-Towner Act. --- afterlife of slavery. --- birth stories. --- birth workers. --- comprehensive care. --- definition of prematurity. --- diagnostic lapse. --- doula. --- doulas. --- etiology. --- hardy babies. --- labor. --- medical encounters. --- medical racism. --- midwives. --- misdiagnosis. --- model of care. --- neonatal intensive care unit. --- neonatologists. --- obstetric hardiness. --- polio. --- premature birth. --- preventive approaches. --- race and pregnancy. --- racial disparity. --- racial politics. --- racial science. --- racism. --- technologies of saving. --- temporality.
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Dear Readers, Oncolytic Viruses (OV) are self-propagating agents that can selectively induce the lysis of cancer cells while sparing normal tissues. OV-mediated cancer cell death is often immunogenic and triggers robust anticancer immune responses and immunoconversion of tumor microenvironments. This makes oncolytic virotherapy a promising new form of immunotherapy and OVs ideal candidates for combination therapy with other anticancer agents, including other immunotherapeutics. There are more than 40 OVs from nine different families in clinical development and many more at the preclinical stage. Each OV has its own unique characteristics, its pros and cons. Although herpes simplex virus is currently the lead clinical agent, a real champion among the OVs has not yet emerged, justifying the continuous development and optimization of these agents. This book, “Oncolytic Virus Immunotherapy”, summarizes the state-of-the-art and gives a comprehensive overview of the OV arena with a particular focus on new trends, directions, challenges, and opportunities.
oncolytic viruses --- melanoma --- immunotherapy --- checkpoint inhibitors --- combinatory therapy --- reovirus --- oncolytic virus --- adenovirus --- oncolytic --- virotherapy --- targeting --- immunogenic cell death --- αvβ6 integrin --- oncolytic adenovirus --- cancer immunotherapy --- multi-stage --- immunostimulatory --- arming --- HSV-1 --- clinical trials --- newcastle disease virus --- NDV --- cancer --- immune checkpoint inhibitor --- PD-1 --- PD-L1 --- CTLA-4 --- type I interferon --- herpes simplex virus --- retargeted virus --- tropism retargeting --- tumor --- checkpoint inhibitor --- vaccination --- antigen-agnostic vaccination --- HER2 --- parvovirus --- tumor microenvironment --- combination therapy --- glioblastoma --- pancreatic cancer --- colorectal cancer --- measles virus --- vector engineering --- immune checkpoint blockade --- antitumor immune response --- delivery --- genetic modification --- biomarkers --- personalized oncolyticvirotherapy --- class I HLA --- immunosurveillance --- immunoediting --- oncogenic signaling --- RAS --- DNA methyltransferase inhibitor (DNMTi) --- viral mimicry --- epigenetic silencing --- adoptive T cell therapy --- CAR T cell --- pancreatic ductal adenocarcinoma --- vesicular stomatitis virus --- small molecule --- cancer immune therapy --- cancer therapy --- n/a
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Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.
Zika virus --- nucleoside analogues --- antiviral agents --- NS5 --- prodrugs --- ProTides --- neural stem cells --- RNA-dependent RNA polymerase --- cytomegalovirus --- latent infection --- TALEN --- Surveyor nuclease mutation detection assay --- ie-1 gene --- quantitative real-time PCR --- Epstein–Barr virus --- herpes viruses --- lytic gene expression --- Burkitt lymphoma cells --- clozapine --- antipsychotic drug --- antiviral drug --- enteroviruses --- coxsackievirus B4 --- persistent infection --- fluoxetine --- resistance --- mutations --- herpes B virus --- macacine herpesvirus-1 --- genistein --- flavonoids --- acyclovir --- ganciclovir --- Plantago asiatica --- Clerodendrum trichotomum --- RSV --- therapeutic effects --- acteoside --- human antimicrobial peptides --- antiviral strategies --- defensins --- cathelicidins --- hepcidins --- transferrins --- influenza A virus --- brevilin A --- antiviral --- sesquiterpene lactone --- replication --- PRRSV --- polyethylenimine --- PEI --- virion internalization --- endocytosis --- HIV --- pediatrics --- Ethiopia --- pre-treatment drug resistance --- combination antiretroviral therapy (cART) --- dried plasma spots --- dried blood spots --- sphingolipids --- glycosphingolipids --- viruses --- lipid biosynthesis --- flavivirus --- Japanese encephalitis virus --- furin inhibitor --- precursor membrane protein --- measles virus --- central nervous system --- tropism --- treatments --- porcine reproductive and respiratory syndrome virus --- ginsenoside Rg1 --- antiviral activity --- pro-inflammatory factor --- NF-κB signaling pathway --- acute/latent infection --- congenital infection --- antiviral agent --- therapeutic strategies --- nucleic acid-based therapeutic approach --- HCMV vaccine --- adoptive cell therapy --- Rev response element --- chemical footprinting --- SHAPE --- drug discovery --- branched peptides --- herpesvirus --- immediate-early --- IE1 --- IE2 --- ribozyme --- RNA interference --- CRISPR/Cas --- small molecule --- orthohantavirus --- phenyl-benzotriazoles --- C-FRA --- Porcine circovirus type 2 --- epigallocatechin gallate --- heparan sulfate --- antiviral effect --- virus attachment --- microvirin --- lectin --- human immunodeficiency virus --- hepatitis C virus --- antiviral inhibitor --- non-immunogenic --- viral entry --- protein drugs --- LUMS1 --- oleanane-type derivatives --- influenza A virus (IAV) --- virus entry inhibitors --- hemagglutinin (HA) --- n/a --- Epstein-Barr virus
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