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Phenolic compounds are an extremely diverse class of ubiquitous secondary metabolites produced by a variety of organisms playing different biological roles. They have numerous types of demonstrated bioactivities, including antioxidant, antimicrobial, anti-inflammatory, antitumoral, immunomodulator, neuroprotective, cardioprotective, and antidiabetic activities. Marine organisms produce a vast collection of unique phenolic structures, some of them not found in terrestrial habitats. Progress in different aspects is rapidly advancing, and this Special Issue will provide updated information and recent studies on marine phenolics. Specially, this issue is focused on their chemical characterization, elucidation of their structures, evaluation of their biological properties and mechanisms of action, efficient extraction and purification technologies, development of value-added applications, as well as formulation of novel products.

ultrasound assisted extraction --- conventional extraction --- polyphenols --- phlorotannin --- macroalgae --- antioxidant capacity --- seaweeds --- antioxidant potential --- LC-ESI-QTOF-MS/MS --- HPLC-PDA --- seaweed polyphenols --- hypoglycemic effect --- starch digestion --- enzyme inhibition --- cochayuyo --- seaweed polyphenolics --- polyphenolics extractions --- phlorotannins --- bromophenols --- flavonoids --- phenolic terpenoids --- polyphenolics bioactivities --- marine phenolics --- emerging technologies --- extraction --- Ascophyllum --- seaweed --- health benefits --- isomers --- LC-MSn --- diversity --- phenolics --- simple phenolics --- seawater --- algae --- seagrass --- biological activity --- brown seaweeds --- microwave-assisted extraction --- response surface methodology --- antioxidant --- antiradical activity --- xanthine oxidase --- α-glucosidase

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Biosensors are analytical devices used for the detection of a chemical substance, or analyte, which combines a biological component with a physicochemical detector. Detection and quantification are based on the measurement of the biological interactions. The biological element of a biosensor may consist of tissues, microorganisms, organelles, cell receptors, enzymes, antibodies and nucleic acids. These devices have been shown to have a wide range of applications in a vast array of fields of research, including environmental monitoring, food analysis, drug detection and health and clinical assessment, and even security and safety. The current Special Issue, “Biosensors: 10th Anniversary Feature Papers”, addresses the existing knowledge gaps and aids the advancement of biosensing applications, in the form of six peer-reviewed research and review papers, detailing the most recent and innovative developments of biosensors.

antioxidants --- biosensor --- nanomaterials --- vasodilator activity --- breast cancer screening --- imaging biomarker --- deep sparse autoencoder --- dimensionality reduction --- deep-learning features --- Bioassays --- high performance thin layer chromatography --- endocrine disrupting compounds --- fluorescent proteins --- wastewater --- electromagnetic piezoelectric acoustic sensor --- quartz --- adsorption --- diagnostics --- extracellular vesicle --- dithiocarbamate fungicides --- chromatography --- Raman spectroscopy --- sensors --- enzyme inhibition --- voltammetry --- biosensors --- tobacco mosaic virus (TMV) --- capacitive field-effect sensor --- bi-enzyme biosensor --- enzyme-logic gate --- urease --- penicillinase

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The G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Sciences (PIBOC FEB RAS) was founded in 1964 in Vladivostok in the Far East of Russia. Over many years, we have been carrying out studies on the natural products of both marine and terrestrial origin. In collaboration with many Russian and foreign scientists, we have investigated many hundreds of diverse biomolecules, including steroids and terpenoids, quinoid compounds and alkaloids, polysaccharides and lipids, enzymes and lectins, proteins, and peptides. The Institute has a collection of marine microorganisms (KMM) PIBOC, which includes more than 4000 strains of marine bacteria and more than 1000 strains of marine fungi. The biological activity of natural compounds is also being studied. This book includes the 14 manuscripts which covered almost all aspects of PIBOC research activity in the fields of bioorganic chemistry, biochemistry, organic synthesis of natural compounds, marine microbiology, and genetic engineering, and we hope it will provide interesting new information for scientists working in these fields.

polyhydroxylated steroids --- NMR spectra --- starfish --- Anthenoides laevigatus --- cytotoxicity --- soft agar assay --- kainic acid --- domoic acid --- dysiherbaine --- neodysiherbaine A --- marine bacteria --- whole genome sequence --- porin --- amino acids composition --- bilayer lipid membrane --- pore-forming activity --- spatial structure --- phlorotannins --- phlorethols --- anticancer activity --- colorectal cancer --- radiosensitizer --- radiotherapy --- 1,4-naphthoquinones --- quinoid compounds --- thioglycosides --- quinone-sugar conjugates --- cytotoxic activity --- antibiotic activity --- histochrome --- echinochrome A --- oxidative degradation --- HPLC–DAD–MS --- NMR --- actinoporin --- sea anemone --- Heteractis crispa --- anti-migratory activity --- glycosphingolipids --- cerebrosides --- peroxidation products --- structure elucidation --- allylic thioether --- ESI-MS --- GC-MS --- mass spectra --- glass sponge --- isomalabaricanes --- Stelletta sp. --- marine sponge --- terpenoid --- Cobetia amphilecti --- Cobetia litoralis --- Cobetia pacifica --- Cobetia marina --- Cobetia crustatorum --- identification markers --- alkaline phosphatase PhoA --- lanosterol 14-alpha demethylase --- flavonoids --- enzyme inhibition --- surface plasmon resonance --- spectral titration --- molecular docking --- Zobellia --- genomes --- polysaccharide lyase family 7 --- alginate utilization system --- paralogs --- orthologs --- recombinant phospholipase A1 --- Yersinia pseudotuberculosis --- inclusion bodies --- fusion protein --- green fluorescent protein --- porin gene expression --- antibiotic stress --- phenotypic heterogeneity --- n/a --- HPLC-DAD-MS

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Milk processing is one of the most ancient food technologies, dating back to around 6000 B.C. A huge number of milk products have been developed worldwide, representing a spectacular example of biodiversity and a priceless cultural heritage. After millennia of unanimous appreciation as a pillar of human nutrition, a series of questions about the desirability of their wide consumption have been raised. In the light of the growing threat deriving mostly from the spread of veganism and health consciousness, improving milk prcoessing safety and dairy nutritional characteristics, as well as deepening their functional characteristics, are of a primary exigency. This Special Issue contains several articles focusing on this hot topic, all of which add knowledge to the field and supply interesting ideas for developing new products and processes.

milk composition --- Parmigiano Reggiano cheese --- cheese-making efficiency --- curd fines --- cheese-making losses --- zinc --- ewes’ milk cheese --- rumenic acid --- zinc-dependent enzyme --- volatile compound --- cheesemaking --- donkey milk --- fatty acids --- sensory analysis --- VOC --- starch --- yogurt --- rheology --- sensory --- texture --- defatted cheese --- peptides --- amino acids --- bioactivity --- digestibility --- cheese quality --- mountain cheese --- fatty acid profile --- volatile organic compounds --- sensory properties --- milk clotting --- cheese --- kiwifruit --- actinidin --- nutraceutical properties --- microstructure --- Raman spectroscopy --- confocal laser scanning microscopy --- cheese freezing --- cream cheese --- NMR spectroscopy --- cryoprotectants --- black tea --- acidified dairy gel --- textural property --- antioxidant capacity --- functional yogurt --- fenugreek and Moringa oleifera seed flours --- total phenolic content --- antioxidant activity --- antibacterial activity --- mineral content --- Rubus suavissimus S. Lee (Chinese sweet tea) --- antioxidant --- anticancer --- antihypertensive --- polymerized goat milk whey protein --- soy isoflavones --- nanoparticle --- physicochemical property --- milk fat globules --- bovine milk proteins --- milk fat globule membrane --- comparative proteomics --- infant formula preparation --- n/a --- panela cheese --- angiotensin-converting enzyme inhibition --- probiotic addition --- DPPH --- ABTS --- ewes' milk cheese

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This theme issue is to celebrate Professor Robert Verpoorte’s 75th birthday. Prof. Verpoorte has been working in Leiden University over 40 years. There is no need to dwell upon the contributions of Dr. Verpoorte to plant-derived natural products research during his whole life. Dr. Verpoorte was a highly productive scientist throughout his academic career, with over 800 scientific publications in the form of research papers, books, and book chapters. His research interests are very diverse, cover- ing numerous topics related to plant-based natural products such as plant cell biotech- nology, biosynthesis, metabolomics, genetic engineering, and green technology, as well as the isolation of new biologically active compounds. He has left indelible footprints in all these fields, and he is widely recognised as a pioneer in the work of the biosynthesis of indole alkaloids, NMR-based metabolomics, and green technology in natural products production. As close friends and colleagues who have been in nearly daily contact with him over the last 20 years viewing all of these remarkable scientific contributions, we felt compelled to recognize this by the publication of a Special Issue of this journal dedicated to him.Thus, this Special Issue has now finally been released with the help of many of his colleagues and former students as a token of our gratitude to his impressive work.The Special Issue covers five main natural products topics: (1) chemical profiling and metabolomics, (2) separation/isolation and identification of plant specialized metabolites, (3) pharmacognosy of natural products to identify bioactive molecules from natural prod- ucts, (4) novel formulation of natural products, and (5) overview of natural products as a source of bioactive molecules.

natural extract --- glycerin --- chemical profiling --- centrifugal partition chromatography --- 13C nuclear magnetic resonance --- cosmetic industry --- Psychotria malayana Jack --- type 2 diabetes --- α-glucosidase inhibitors --- LC-MS --- metabolomics --- molecular docking --- colorectal cancer --- HCT 116 --- telomerase --- telomerase inhibitor --- berberine --- downregulation --- cell cycle arrest --- telomere erosion --- molecular imaging --- direct analysis in real-time mass spectrometry --- ephedra alkaloids --- ephedrine --- methylephedrine --- Ephedra sinica --- natural products --- dereplication --- databases --- spectroscopy --- taxonomy --- molecular structures --- lignans --- secoisolariciresinol --- RNA interference --- flax --- osmotic stress --- 1H-NMR --- ionic liquids --- oxypeucedanin hydrate --- byakangelicin --- A. dahurica --- back-extraction --- enrichment --- plum brandy --- GC-FID-MS --- enzyme inhibition assay --- antibacterial assay --- effect-directed analysis --- bioassay --- botanicals --- health food --- protein tyrosine phosphatases (PTPs) --- PTP-MEG2 --- phloridzin --- glucose-uptake --- Eleutherococcus senticosus --- fruits --- eleutherosides --- nutri-pharmacological --- herbs --- inflammation --- docking --- NuBBE database --- chalcones --- Nacobbus aberrans --- nematicidal activity --- α-terthienyl --- stigmasterol --- quercetagetin derivatives --- 9-O-angeloyl-retronecine N-oxide --- alkaloid --- Solanaceae --- tropane --- indole --- pyrrolidine --- Datura --- terpenoid --- signaling --- chemical cue --- kairomone --- potentiation --- cytotoxic activity --- NMR --- Ononis diffusa --- Ononis variegata --- oxylipins --- toronjil --- Mexican agastache --- aromatic plants --- weld --- Reseda luteola L. --- natural yellow dye --- μ-analysis --- micro-extraction of wool --- UHPLC --- fingerprinting --- flavones --- structure elucidation --- n/a