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Cancer patients have benefitted greatly from recent advances in the drugs, dose regimens, and combinations used to treat their primary tumor and for the treatment or prevention of spread of their disease. Due to the advances in chemotherapy and other aspects of prevention, early detection, and treatment modalities, an increasing percentage of patients are surviving the disease. For some types of cancer, the majority of patients live decades beyond their diagnosis. For this they are forever thankful and appreciative of the drugs that helped lead to this increased survival rate. But no drug is devoid of adverse effects. This also applies to chemotherapeutic agents. The acute cytotoxic effects of these agents are well known––indeed are often required for their therapeutic benefit. The chronic adverse effects are varied and in some cases less well known. With the increase in survival rates, there has emerged a new awareness of these chronic adverse effects.

Antineoplastic agents --Side effects. --- Cancer --Chemotherapy --Complications. --- Cognition disorders. --- Neurotoxic agents. --- Cancer --- Cognition disorders --- Antineoplastic agents --- Neurotoxic agents --- Nervous System Diseases --- Kinetics --- Therapeutics --- Investigative Techniques --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Poisoning --- Therapeutic Uses --- Mental Disorders --- Substance-Related Disorders --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Pharmacologic Actions --- Psychiatry and Psychology --- Chemical Actions and Uses --- Chemical Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Drug Therapy --- Pharmacokinetics --- Cognition Disorders --- Neurotoxicity Syndromes --- Antineoplastic Agents --- Models, Animal --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Complications --- Side effects --- Complications. --- Side effects. --- Neuropoisons --- Neurotoxicants --- Neurotoxins --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Cognitive disorders --- Complications and sequelae --- Medicine. --- Cancer research. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Poisons --- Drugs --- Psychology, Pathological --- Oncology. --- Tumors --- Health Workforce --- Biomedicine, general. --- Neurotoxicity Syndromes. --- Drug-Related Side Effects and Adverse Reactions. --- Models, Animal. --- chemically induced. --- pharmacokinetics. --- toxicity. --- Animals, Model. --- Encephalopathy, Toxic --- Nervous System Poisoning --- Neurotoxic Disorders --- Neurotoxin Diseases --- Neurotoxin Disorders --- Toxic Encephalitis --- Poisoning, Nervous System --- Encephalitides, Toxic --- Encephalitis, Toxic --- Encephalopathies, Toxic --- Nervous System Poisonings --- Neurotoxic Disorder --- Neurotoxicity Syndrome --- Neurotoxin Disease --- Neurotoxin Disorder --- Poisonings, Nervous System --- Syndrome, Neurotoxicity --- Syndromes, Neurotoxicity --- Toxic Encephalitides --- Toxic Encephalopathies --- Toxic Encephalopathy --- Adverse Drug Event --- Adverse Drug Reaction --- Drug Side Effects --- Drug Toxicity --- Side Effects of Drugs --- Toxicity, Drug --- Adverse Drug Events --- Adverse Drug Reactions --- Drug Event, Adverse --- Drug Events, Adverse --- Drug Reaction, Adverse --- Drug Reactions, Adverse --- Drug Related Side Effects and Adverse Reactions --- Drug Side Effect --- Drug Toxicities --- Effects, Drug Side --- Reactions, Adverse Drug --- Side Effect, Drug --- Side Effects, Drug --- Toxicities, Drug --- Pharmaceutical Preparations --- Contraindications, Drug --- Drug Interactions --- Clinical Trials, Phase IV as Topic --- adverse effects --- toxicity --- Experimental Animal Models --- Laboratory Animal Models --- Animal Model --- Animal Model, Experimental --- Animal Model, Laboratory --- Animal Models --- Animal Models, Experimental --- Animal Models, Laboratory --- Experimental Animal Model --- Laboratory Animal Model --- Model, Animal --- Model, Experimental Animal --- Model, Laboratory Animal --- Models, Experimental Animal --- Models, Laboratory Animal --- Animal Experimentation