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Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Protease inhibitors. --- Proteolytic enzymes. --- Virus inhibitors.

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Antiviral agents --- Chemotherapy --- Virus inhibitors --- Testing --- Congresses --- Congresses --- Testing --- Congresses

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Antiviral agents --- -#Lilly --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus diseases --- Virus inhibitors --- Congresses --- Chemotherapy --- #Lilly

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With the increasing emergence of viral infections worldwide, researchers are working to develop new and non-conventional treatments for infectious diseases. This is particularly true for SARS-CoV-2, which initiated a pandemic in 2019. With a focus on coronavirus, this book provides an overview of antiviral agents and new approaches to drug design. It includes five chapters that address new avenues for drug discovery, reprofiling of current drugs, computer-aided drug design, and more.

Antiviral agents. --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus diseases --- Virus inhibitors --- Chemotherapy

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The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies.

Antiviral agents. --- Virus diseases --- Chemotherapy. --- Antiviral agents --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus inhibitors --- Chemotherapy --- Pharmacology