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"This fully revised Fourth Edition to a best-selling resource provides the reader with a hands-on guide to computational biology, primarily in the area of sequence analysis. The subject matter will cover a broad spectrum of concepts in bioinformatics, beginning with an overview of biological databases and ending with a series of chapters on predictive and comparative algorithms. Using relevant biological examples, the book will provide background on and strategies for using many of the most powerful and commonly-used algorithms for sequence-based discovery. Given the explosion in the number of organisms whose genomes have been sequenced over the last several years, the emergence of new types of data sets (particularly those derived using next-generation sequencing technologies), and increasing emphasis on being able to make effective use of "big data", the book is both timely and important to investigators in molecular biology and related fields. With a full-color, enlarged page design, this edition offers the most readable, up-to-date, and thorough introduction to the field for biologists. The new "Foundations" section insures that readers have a firm understanding of the technologies that generate the data, as well as the essential statistical and programming tools. Features include special boxes, enhanced use of real examples, and problem sets with answers provided on the book's dedicated website (www.wiley.com/bioinformatics). A glossary and appendix of sample file formats rounds out the book's reader-friendly, 'hands-on' treatment"--

Computational Biology --- Sequence Analysis --- Base Sequence --- Databases, Nucleic Acid --- Databases, Protein --- methods --- Base Sequence. --- Databases, Nucleic Acid. --- Databases, Protein. --- Methods. --- methods. --- Bioinformatics --- Protein Structure Databases --- SwissProt --- Amino Acid Sequence Databases --- Databases, Amino Acid Sequence --- Protein Databases --- Protein Sequence Databases --- SWISS-PROT --- Database, Protein --- Database, Protein Sequence --- Database, Protein Structure --- Databases, Protein Sequence --- Databases, Protein Structure --- Protein Database --- Protein Sequence Database --- Protein Structure Database --- SWISS PROT --- Sequence Database, Protein --- Sequence Databases, Protein --- Structure Database, Protein --- Structure Databases, Protein --- DNA Databanks --- DNA Sequence Databases --- European Molecular Biology Laboratory Nucleotide Sequence Database --- Nucleic Acid Sequence Databases --- RNA Sequence Databases --- DDBJ --- DNA Data Bank of Japan --- DNA Data Banks --- DNA Databases --- Databases, DNA --- Databases, DNA Sequence --- Databases, Nucleic Acid Sequence --- Databases, RNA --- Databases, RNA Sequence --- EMBL Nucleotide Sequence Database --- GenBank --- Nucleic Acid Databases --- RNA Databases --- Bank, DNA Data --- Banks, DNA Data --- DNA Data Bank --- DNA Databank --- DNA Database --- DNA Sequence Database --- Data Bank, DNA --- Data Banks, DNA --- Databank, DNA --- Databanks, DNA --- Database, DNA --- Database, DNA Sequence --- Database, Nucleic Acid --- Database, RNA --- Database, RNA Sequence --- Nucleic Acid Database --- RNA Database --- RNA Sequence Database --- Sequence Database, DNA --- Sequence Database, RNA --- Sequence Databases, DNA --- Sequence Databases, RNA --- Genetic Testing --- Gene Library --- DNA Fingerprinting --- DNA Sequences --- DNA Sequence --- Nucleotide Sequence --- RNA Sequence --- Base Sequences --- Nucleotide Sequences --- RNA Sequences --- Sequence, Base --- Sequence, DNA --- Sequence, Nucleotide --- Sequence, RNA --- Sequences, Base --- Sequences, DNA --- Sequences, Nucleotide --- Sequences, RNA --- Genes --- Nucleotides --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Data processing

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Human gene mapping --- Chromosome Mapping --- Genetic Engineering --- Genome, Human --- Confidentiality --- Genetic Enhancement --- DNA Fingerprinting --- Government Regulation --- Health Care Rationing --- Risk --- Social Change --- Social Justice --- Pedigree --- Social Control, Formal --- Databases, Nucleic Acid --- Ethics --- Ethics, Medical --- Genetic Testing --- Prejudice --- Health --- Delivery of Health Care --- Economics --- Databases, Factual --- Resource Allocation --- Insurance --- Minority Groups --- Prenatal Diagnosis --- Eugenics --- Genetic Diseases, Inborn --- Genetics --- Sociology --- Health Services Accessibility --- Forensic Medicine --- Databases as Topic --- Genetic Techniques --- Ethics, Clinical --- Population Characteristics --- Jurisprudence --- History --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Human Rights --- Socioeconomic Factors --- Principle-Based Ethics --- Biology --- Health Care Economics and Organizations --- Health 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Psychology --- Psychologies, Social --- Social Psychologies --- Patient's Rights --- Patients' Rights --- Right to Treatment --- Patient Right --- Patient's Right --- Patients Rights --- Patients' Right --- Right to Treatments --- Right, Patient --- Right, Patient's --- Right, Patients' --- Rights, Patient --- Rights, Patient's --- Rights, Patients' --- Treatment, Right to --- Treatments, Right to --- Morality --- PL93-641 --- Public Law 93-641 --- Health and Welfare Planning --- National Health Planning and Resources Development Act of 1974 --- Planning, Health and Welfare --- State Health Planning, United States --- Planning, Health --- Public Law 93 641 --- Services, Genetic --- Genetic Service --- Service, Genetic --- Jurisprudence, Psychiatric --- Psychiatric Jurisprudence --- Psychiatry, Forensic --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- General Social Development and Population --- Computer 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--- Storage, Data --- Forensic Science --- Science, Forensic --- Sciences, Forensic --- Community Financing --- Grants --- Organized Financing --- Financing, Community --- Grant --- Enhancement Technologies --- Enhancement, Biomedical --- Biomedical Enhancements --- Enhancement Technology --- Enhancements, Biomedical --- Technologies, Enhancement --- Technology, Enhancement --- Genetic Data Banks --- Genetic Data Bases --- Genetic Databanks --- Genetic Information Databases --- Genetic Databases --- Genetic Sequence Databases --- OMIM --- Online Mendelian Inheritance In Man --- Bank, Genetic Data --- Banks, Genetic Data --- Data Bank, Genetic --- Data Banks, Genetic --- Data Base, Genetic --- Data Bases, Genetic --- Databank, Genetic --- Databanks, Genetic --- Database, Genetic --- Database, Genetic Information --- Database, Genetic Sequence --- Databases, Genetic Information --- Databases, Genetic Sequence --- Genetic Data Bank --- Genetic Data Base --- Genetic Databank --- Genetic Database --- Genetic Information Database --- Genetic Sequence Database --- Information Database, Genetic --- Information Databases, Genetic --- Sequence Database, Genetic --- Sequence Databases, Genetic --- Science, Social --- Sciences, Social --- Social Science --- Probabilities --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Aspects, Historical --- Historical Aspects --- Aspect, Historical --- Historical Aspect --- Histories --- Constitutional Law --- Court Decision --- Law --- Legal Aspects --- Legal Obligations --- Legal Status --- State Interest --- Litigation --- Medical Jurisprudence --- Aspect, Legal --- Aspects, Legal --- Constitutional Laws --- Court Decisions --- Decision, Court --- Decisions, Court --- Interest, State --- Interests, State --- Jurisprudence, Medical --- Law, Constitutional --- Laws --- Laws, Constitutional --- Legal Aspect --- Legal Obligation --- Litigations --- 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--- Healthcare Economics --- Care Economic, Health --- Economic, Health --- Economic, Health Care --- Economic, Healthcare --- Economics, Health Care --- Health Care Economic --- Health Economic --- Healthcare Economic --- Social Inequalities --- Social Inequality --- Inequalities, Social --- Inequality, Social --- Diagnostic Testing --- Testing, Diagnostic --- Incidence --- Behavior And Behavior Mechanism --- Fetal Diagnosis --- Fetal Imaging --- Fetal Screening --- Diagnosis, Fetal --- Fetal Diagnoses --- Fetal Imagings --- Fetal Screenings --- Imaging, Fetal --- Screening, Fetal --- Access To Medicines --- Access to Contraception --- Access to Health Services --- Access to Medications --- Access to Therapy --- Access to Treatment --- Contraception Access --- Contraceptive Access --- Medication Access --- Access To Medicine --- Access to Contraceptions --- Access to Medication --- Access to Therapies --- Access to Treatments --- Access, Contraception --- Access, Contraceptive --- 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